C-Reactive Protein: Eighty Years from Discovery to Emergence as a Major Risk Marker for Cardiovascular Disease

Biochemical markers of psoriasis as a metabolic disease

“…A number of studies have demonstrated a link between the concentration of C-reactive protein and cardiovascular disease, BMI, waist to hip ratio, hypertriglyceridemia, increased levels of glucose, abnormal blood pressure, and insulin resistance [214][215][216].…”

C-Reactive Protein Adversely Alters the Protein–Protein Interaction of the Endothelial Isoform of Nitric Oxide Synthase

“…C-reactive protein (CRP), 2 a member of the pentraxin family, is the prototypic marker of inflammation in humans (1 ) and is a valid marker of cardiovascular risk (2 ). Mounting data also support a role for CRP in atherothrombosis (3,4 ).…”

The independent associations of HbA1c, C-reactive protein and birth weight with cardiovascular disease, diabetes mellitus and chronic kidney disease in a remote Indigenous Australian community: a prospective cohort study

“…Physical trauma and inflammation produce lesion rupture, which can lead to clinical events such as heart attack and stroke, or resolve with plaque growth [30,33]. Disease progression is marked by an indicator of systemic inflammation, C-reactive protein (CRP) [34,35]. Coronary atherosclerosis is the common cause of heart failure (HF), where disordered calcium signalling to the myofilaments occurs [36].…”

“…A study in 2000-2003 found the prevalence of hypertension across 3 communities from the Top End of the NT ranged from 34% to 54%, 3-8 times the risk compared to the AusDiab cohort with age adjustment [27]. Hypertension was prevalent in just under 30% of those aged [25][26][27][28][29][30][31][32][33][34] years and almost 70% in those aged 55-74 years. Adjusted for age and sex, the prevalence of hypertension in adults aged 25-44 years was 7 fold that of the AusDiab cohort [27].…”

“…The following five decades presented research that confirmed CRP as a marker of systemic inflammation and introduced the potential association between CRP and CVD. Studies until the 1990's were case studies and cross-sectional analyses which were unable to determine if CRP was elevated due to the cardiovascular event or was a marker of the risk prior to the event [34]. In 1996 and 1997, the Multiple Risk Factor Intervention Study (MRFIT) and…”