C-Reactive Protein Drives Potent Clearance of Blood Bacteria in the Liver by Activating the Complement System
Danyu Chen,
Jiao Hu,
Mengran Zhu
et al.
Abstract:Plasma C-reactive protein (CRP) is widely used as a biomarker for bacterial infections due to its massive induction during infections, however, the precise function of CRP in bacterial infections remains undefined. Here we show that CRP enables Kupffer cells (liver macrophages) to capture and eliminate a wide range of encapsulated bacteria from the bloodstream of mice and thereby provides rapid and effective immunity. Mechanistically, CRP binds to the structurally diverse capsular polysaccharides of major Gram… Show more
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