C-Reactive Protein Does Not Predict Therapeutic Response in Patients With Heart Failure: A Meta-Analysis

Jiang, Wen-Hsin; Baker, William B.; Phan, Penny; Chow, Sheryl L.

doi:10.1016/s0735-1097(14)60787-7

Cited by 1 publication

(1 citation statement)

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“…However, despite CRP-lowering effects, a correlation between clinical outcomes and CRP could not be established. More recently, a meta-analysis of randomized clinical trials did not detect any association between baseline CRP concentrations and treatment effect on mortality, readmission or the composite of mortality and readmissions [53]. These data suggest that CRP may be suitable as a marker of prognosis but should not be used to guide therapy in patients with CHF.…”

Section: Other Therapiesmentioning

confidence: 97%

Predicting therapeutic response in patients with heart failure: the story of C-reactive protein

Huynh

Tassell

Chow

2015

Expert Review of Cardiovascular Therapy

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Heart failure continues to be a major public health burden in the USA. With markedly high rates of morbidity and mortality upon diagnosis, effective treatment and prognosis are critical in the management of chronic heart failure. Growing evidence now supports the hypothesis that inflammation plays a key role in the progression and worsening of heart failure. Of the various inflammatory mediators identified, C-reactive protein, an acute phase inflammatory marker, has been associated with poor prognosis in patients with heart failure. Several interventional studies have been investigated to explore C-reactive protein modulation and potential treatment options and health outcomes; however, further studies are warranted before C-reactive protein-targeted therapy may be recommended in the management of heart failure.

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Section: Other Therapiesmentioning

confidence: 97%