C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review

Bansal, Tushika; Pandey, Anita; Asthana, AK

doi:10.7860/jcdr/2014/8355.4646

Cited by 64 publications

(52 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental conformation of the present study further emphasize that another widely prevalent and preventable contributor to the burden of CVD (in form of periodontitis) would be added to the options available to the clinicians and public health practitioners for the control of the epidemic of CVD. 20 Another etiological factor that has been strongly associated with periodontitis as well as CVD is tobacco smoking. Smoking behaviour was categorized as Current smokers, Former smokers and Nonsmokers.…”

Section: Discussionmentioning

confidence: 99%

C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

Gupta

Pradhan

et al. 2017

J Nepal Med Assoc

View full text Add to dashboard Cite

Introduction: Chronic periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss. In addition to declining oral health, there is always low grade infection present in periodontitis. Studies show increased levels of systemic biomarkers in periodontal disease such as CRP, which is considered a key-marker of CVD. Research has also shown positive association between BMI and smoking with periodontitis and CRP. The objective of the study was to assess the levels of CRP in patients with and without periodontitis and their relation with BMI and smoking behaviour.Methods: Patients visiting the Dental department of Bir Hospital were invited to participate in the study. Total 31 subjects in each group: Case (periodontitis) and Control (without periodontitis) were selected using convenience sampling technique. All subjects underwent periodontal examination by a single examiner. Serum CRP samples were taken before periodontal treatment. Data analysis was done by SPSS 17 software program.Results: Increase in mean CRP levels in periodontitis (5.8595mg/L) with high statistical significance (p=0.000) in comparison to subjects without periodontitis (1.1214mg/L) was observed. BMI showed positive association with periodontitis (p=0.046) but not with CRP (0.213). Smoking behaviour showed no significant relation with either CRP (p=0.344) or periodontitis (p=0.541).Conclusions: We found highly significant association between periodontitis and CRP levels but not always with BMI and smoking. CRP, which is an established marker for CVD was significantly increased in periodontal infections. Hence, a close interaction among Physician, Periodontist and Patient to prevent adverse health situations is recommended.Keywords: body mass index; cardiovascular disease; c-reactive protein; periodontitis; smoking; systemic inflammation. [PubMed]

show abstract

Section: Discussionmentioning

confidence: 99%

C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

Gupta

Pradhan

et al. 2017

J Nepal Med Assoc

View full text Add to dashboard Cite

show abstract

“…FoCus delivered reliable phenotype-and serum-data in previous publications (Ji et al, 2017;Munz et al, 2017). Taking limitations of questionnaire-and patient-based data into account, we carefully controlled for influencers and characteristics of periodontitis in the cohort (Bansal, Pandey, Deepa, & Asthana, 2014;Bergstrom & Preber, 1994;Martinez-Canut, Lorca, & Magan, 1995;Tsioufis, Kasiakogias, Thomopoulos, & Stefanadis, 2011). It has to be mentioned that in nested case-control studies, some risk factors might not have been recorded and that case-control studies are prone to bias.…”

Section: Discussionmentioning

confidence: 99%

Secreted frizzled‐related protein 5 serum levels in human periodontitis—A nested case–control study

Wagner

Knappe

Graetz

et al. 2019

J Clinic Periodontology

View full text Add to dashboard Cite

Aim Recombinant secreted frizzled‐related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach. Materials and Methods sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. A total of 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex‐, smoker‐, age‐ and BMI‐matched individuals in a nested case–control design. Results Systemic sFRP5 serum levels were significantly lower in patients with periodontitis and tooth loss (2.5 [0.0–10.4] ng/ml, median [IQR]) compared to patients with periodontitis without tooth loss (6.0 [2.5–15.8] ng/ml, median [IQR], p = 0.04] and matched controls (7.0 [2.5–18.3] ng/ml, median [IQR], p = 0.02). No significant differences in sFRP5 serum levels were found among patients with periodontitis without tooth loss (6.0 [2.5–15.8] ng/ml, median [IQR]) and controls (3.1 [0.0–10.6] ng/ml, median [IQR], p = 0.06). Conclusions sFRP5 might serve as a novel biomarker for periodontitis severity. Modulating the inflammatory background of severe forms of periodontitis, in the time of precision medicine, needs to be revealed in further studies.

show abstract

“…Moreover, the administration of pro-inflammatory cytokines and lipopolysaccharide has been able to induce depressive-like behaviors in rodent studies (Manosso et al, 2013 ; Mello et al, 2013 ; Kurosawa et al, 2015 ; Zhu et al, 2015 ). Critically, periodontal disease is also associated with high levels of systemic inflammation, in particularly, interleukin-6 (IL-6), TNF-α, and C-reactive protein (CRP; Pussinen et al, 2007 ; Bansal et al, 2014 ) that may potentiate inflammatory and oxidative and nitrosative stress processes and thus may lead to a vulnerability to depression (Battino et al, 1999 ; Chapple and Matthews, 2007 ; Berk et al, 2013 ; Bullon et al, 2014 ). Furthermore, periodontal disease may increase the risk for depression through the psychosocial effects (e.g., shame, isolation, embarrassment, loneliness) of poor oral hygiene and halitosis, frequent characteristics of patients with periodontal disease (Morita and Wang, 2001 ; Tsai et al, 2008 ; Pham et al, 2012 ; Silveira et al, 2012 ; Durham et al, 2013 ; Guentsch et al, 2014 ).…”

Section: Periodontal Disease As a Cause Of Depressionmentioning

confidence: 99%

Section: Periodontal Disease As a Cause Of Depressionmentioning

confidence: 99%

Depression and Inflammatory Periodontal Disease Considerations—An Interdisciplinary Approach

Dumitrescu

2016

Front. Psychol.

View full text Add to dashboard Cite

C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review

Cited by 64 publications

References 28 publications

C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

C-reactive Protein in Periodontitis and its Comparison with Body Mass Index and Smoking Behaviour

Secreted frizzled‐related protein 5 serum levels in human periodontitis—A nested case–control study

Depression and Inflammatory Periodontal Disease Considerations—An Interdisciplinary Approach

Contact Info

Product

Resources

About