C-reactive protein, bone loss, fracture, and mortality in elderly women: a longitudinal study in the OPRA cohort

Berglundh, Sofia; Malmgren, Linnea; Luthman, Holger; McGuigan, Fiona; Åkesson, Kristina

doi:10.1007/s00198-014-2951-7

Cited by 57 publications

(37 citation statements)

References 33 publications

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“…Recurrent hemarthrosis produces a repetitive or continuous inflammatory response in haemophilic patients, resulting in osteoclasts secondary activation, increased bone resorption, and consequent bone loss . Previous studies have described elevated C‐reactive protein levels, one of the most commonly used biomarkers of inflammation, in populations of osteoporotic patients . However, the present study is, to our knowledge, the first to demonstrate an association between C‐reactive protein and BMD, showing that haemophilic patients with LBMD had greater probability of having elevated C‐reactive protein levels.…”

Section: Discussioncontrasting

confidence: 40%

“…28 Previous studies have described elevated C-reactive protein levels, one of the most commonly used biomarkers of inflammation, in populations of osteoporotic patients. 26,[31][32][33] However, the present study is, to our knowledge, the first to demonstrate an association between C-reactive protein and BMD, showing that haemophilic patients with LBMD had greater probability of having elevated C-reactive protein levels. This finding highlights the importance of stablishing a clear strategy for the prevention and early treatment of recurrent hemarthrosis to avoid a continuous inflammatory response and the risk of bone loss.…”

Section: Parra Et Al In a Matched Case-control Study Of 62 Participancontrasting

confidence: 47%

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Low bone mineral density and associated factors in patients with haemophilia in Colombia

et al. 2018

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Section: Discussioncontrasting

confidence: 40%

Section: Parra Et Al In a Matched Case-control Study Of 62 Participancontrasting

confidence: 47%

Low bone mineral density and associated factors in patients with haemophilia in Colombia

et al. 2018

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“…In the elderly women the results appear contradictory; no appreciable genotype related differences on BMD or QUS yet a tendency towards higher fracture incidence despite lower CRP levels. We interpret these observations to support a role for ALOX15 in modulating inflammatory cytokines [12] while suggesting that fractures are not directly related to increased inflammatory activity, at least not as reflected by serum CRP levels [39]. Unfortunately, other inflammatory biomarkers were not available and neither fracture nor CRP was available in PEAK--25, which is an undoubted limitation of the study.…”

Section: Discussionmentioning

confidence: 76%

“…CRP levels >10 mg/ml was assumed to result from acute inflammation and subsequently 77 women were excluded from the analysis. Since the lowest detectable limit for CRP was 0.6 mg/L, missing (undetectable) values were imputed [39].…”

Section: Analysis Of C--reactive Proteinmentioning

confidence: 99%

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

Herlin

McGuigan

Luthman

et al. 2015

Bone

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“…(8)(9)(10)(11) However, high levels of sUA could cause oxidative stress and microinflammation as a pro-oxidant. (7,12,13) Thus, it is also possible that high sUA levels might have a deleterious effect on bone, (14,15) but Mendelian randomization analyses do not support a causal effect of sUA on BMD. (16,17) It remains poorly understood whether sUA levels affect BMD or fracture risk.…”

Section: Introductionmentioning

confidence: 99%

Gout and the Risk of Non-vertebral Fracture

Kim

Paik

et al. 2016

Journal of Bone and Mineral Research

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Prior studies suggest an association between osteoporosis, systemic inflammation and pro-inflammatory cytokines such as IL-1 and IL-6. Conflicting findings exist on the association between hyperuricemia and osteoporosis. Furthermore, it remains unknown whether gout, a common inflammatory arthritis, affects fracture risk. Using data from a US commercial health plan (2004–2013), we evaluated the risk of non-vertebral fracture (i.e. forearm, wrist, hip and pelvis) in patients with gout versus those without. Gout patients were identified with ≥2 diagnosis codes and ≥1 dispensing for a gout-related drug. Non-gout patients, identified with ≥2 visits coded for any diagnosis and ≥1 dispensing for any prescription drugs, were free of gout diagnosis and received no gout-related drugs. Hip fracture was the secondary outcome. Fractures were identified with a combination of diagnosis and procedure codes. Cox proportional hazards models compared the risk of non-vertebral fracture in gout patients versus non-gout, adjusting for over 40 risk factors for osteoporotic fracture. Among gout patients with baseline serum uric acid (sUA) measurements available, we assessed the risk of non-vertebral fracture associated with sUA. We identified 73,202 gout and 219,606 non-gout patients, matched on age, sex, and the date of study entry. The mean age was 60 years and 82% were men. Over the mean 2-year follow-up, the incidence rate of non-vertebral fracture per 1,000 person-years was 2.92 in gout and 2.66 in non-gout. The adjusted hazard ratio (HR) was 0.98 (95%CI 0.85–1.12) for non-vertebral fracture and 0.83 (95%CI 0.65–1.07) for hip fracture in gout versus non-gout. Subgroup analysis (n=15,079) showed no association between baseline sUA and non-vertebral fracture (HR 1.03, 95%CI 0.93–1.15), adjusted for age, sex, comorbidity score and number of any prescription drugs. Gout was not associated with a risk of non-vertebral fracture. Among patients with gout, sUA was not associated with the risk of non-vertebral fracture.

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C-reactive protein, bone loss, fracture, and mortality in elderly women: a longitudinal study in the OPRA cohort

Cited by 57 publications

References 33 publications

Low bone mineral density and associated factors in patients with haemophilia in Colombia

Low bone mineral density and associated factors in patients with haemophilia in Colombia

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

Gout and the Risk of Non-vertebral Fracture

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