C-reactive protein as an available biomarker determining mental component of health-related quality of life among individuals with spinal cord injury

Sabour, Hadis; Latifi, Sahar; Soltani, Zahra; Shakeri, Hania; Javidan, Abbas Norouzi; Ghodsi, Seyed-Mohammad; Hadian, Mohammad Reza; Razavi, Seyed-Hassan Emami

doi:10.1080/10790268.2016.1139771

Cited by 9 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, compared with participants without fatigue, participants with fatigue and low-grade inflammation as measured by CRP were shown to have mental health problems, including psychological distress, depression, and sleep problems [ 72 ]. Previously, etiological studies showed a negative association between serum CRP levels and the SF-36 MH score in patients with a neural injury, such as spinal cord injury [ 21 ]. Depressed participants were reported to have significantly higher serum C3 levels than healthy participants [ 74 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Uchio¹,

Kawasaki²,

Okuda-Hanafusa³

et al. 2021

Nutr J

View full text Add to dashboard Cite

Background The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health. Methods We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a t test (significance level, p < 0.05). Results After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score (p < 0.05). Conclusion CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance. Trial registration UMIN-CTR, UMIN000037370. Registered 14 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607

show abstract

Section: Discussionmentioning

confidence: 99%

“…High systemic levels of these inflammatory markers are well known to be associated with increased risk for chronic inflammatory diseases [ 2 , 19 , 20 ]. In addition, elevation of circulating levels of CRP and C3 may be associated with impaired quality of life (QOL) and mood disturbance [ 21 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Uchio¹,

Kawasaki²,

Okuda-Hanafusa³

et al. 2021

Nutr J

View full text Add to dashboard Cite

show abstract

“…Differences in lipid profiles have been observed by level of injury and sex for people with SCI. Sabour et al [ 99 ], Jörgensen et al [ 75 ], and Farkas et al [ 5 ] found that men with SCI had significantly lower HDL-C levels than women with SCI [ 75 ]. In addition, Farkas et al [ 5 ] observed that men with SCI had a higher TC:HDL-C ratio than women with SCI.…”

Section: Dyslipidemia After Scimentioning

confidence: 99%

The Diagnosis and Management of Cardiometabolic Risk and Cardiometabolic Syndrome after Spinal Cord Injury

Farkas

Burton

McMillan

et al. 2022

JPM

View full text Add to dashboard Cite

Individuals with spinal cord injuries (SCI) commonly present with component risk factors for cardiometabolic risk and combined risk factors for cardiometabolic syndrome (CMS). These primary risk factors include obesity, dyslipidemia, dysglycemia/insulin resistance, and hypertension. Commonly referred to as “silent killers”, cardiometabolic risk and CMS increase the threat of cardiovascular disease, a leading cause of death after SCI. This narrative review will examine current data and the etiopathogenesis of cardiometabolic risk, CMS, and cardiovascular disease associated with SCI, focusing on pivotal research on cardiometabolic sequelae from the last five years. The review will also provide current diagnosis and surveillance criteria for cardiometabolic disorders after SCI, a novel obesity classification system based on percent total body fat, and lifestyle management strategies to improve cardiometabolic health.

show abstract

“…Recent studies suggest the role of inflammatory and endocrine clinical blood markers, including inflammatory cytokines, C-reactive protein, and dehydroepiandrosterone (DHEA) in the development and chronicity of symptoms, particularly with mobility limitation, depression, sleep deprivation, fatigue, and HRQoL [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. To the best of our knowledge, there is limited evidence on the associations of these clinical blood markers with symptom burden and HRQoL.…”

Section: Introductionmentioning

confidence: 99%

Symptom Profiles, Health-Related Quality of Life, and Clinical Blood Markers among Korean Community-Dwelling Older Adults Living with Chronic Conditions

Park

Lukkahatai

Perrin

et al. 2021

IJERPH

View full text Add to dashboard Cite

Older adults suffer from multiple symptoms, which negatively affects their health-related quality of life. The single-symptom management approach has been less than effective. The data of 2362 Korean community-dwelling older adults aged 70 and above were analyzed in the Korean Frailty and Aging Cohort Study (KFACS) study. A cluster analysis, correlation analysis, and logistic regression were used to analyze the data. We found three symptom clusters: high symptom burden (HSB, n = 1032); pain and fatigue group (PAF, n = 566); and the sleep deprivation group (SDP, n = 764). Participants in the HSB group are more likely to be of old age (OR = 1.1), be female (OR = 2.4), live in a rural area (OR = 1.4), have low physical activity (OR = 0.9), and have multiple chronic conditions (OR = 1.5). The clinical blood markers analysis showed a negative relationship among the physical health, free T4 (r = −0.083, p < 0.01) and insulin (r = −0.084, p < 0.01). The sex-specific blood markers analysis showed differences among three clusters. While free testosterone (male: r = 0.124, female: r = 0.110, p < 0.05) and dehydroepiandrosterone (DHEA) (male: r = 0.352 and female: r = 0.134, p < 0.05) were associated with physical health in the HSB group, only free testosterone was associated with mental health (male: r = −0.093, and female: r = −0.116, p < 0.05) in the SDP group. These findings suggest the potential role of the patient’s sex and sex hormones in symptoms of Korean community-dwelling older adults. Understanding the symptom profiles and impact of biopsychosocial factors may enhance precision symptom management.

show abstract

C-reactive protein as an available biomarker determining mental component of health-related quality of life among individuals with spinal cord injury

Cited by 9 publications

References 47 publications

Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

The Diagnosis and Management of Cardiometabolic Risk and Cardiometabolic Syndrome after Spinal Cord Injury

Symptom Profiles, Health-Related Quality of Life, and Clinical Blood Markers among Korean Community-Dwelling Older Adults Living with Chronic Conditions

Contact Info

Product

Resources

About