C-reactive protein as an acute phase protein in cancer patients

Bolayırlı, Murat; Turna, Hande; Orhanoğlu, Timur; Özaras, Reşat; İlhan, Muzaffer; Özgüroǧlu, Mustafa

doi:10.1007/s12032-007-0012-1

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…In the case of blood sample discrimination by cancer localization, special characteristics of a particular organ carcinogenesis should be taken into account. For instance, increased proteolysis and high concentration of acute phase proteins are characteristic of tumor carcinogenesis of several localizations . Moreover, tumor cells of a different nature are distinguished by high‐glucose consumption .…”

Section: Discussionmentioning

confidence: 85%

“…Cancer progression in the body is characterized by increased proteolysis and concentration of acute phase proteins . The informative Raman bands associated with these changes are Bands 1, 3–5, and 11.…”

Section: Discussionmentioning

confidence: 99%

“…Cancer progression in the body is characterized by increased proteolysis and concentration of acute phase proteins. [28] The informative Raman bands associated with these changes are Bands 1, 3-5, and 11. Band 2, that is associated with the spectral contribution of hemoglobin, can be an indicator of functional disorder in the hematologic system of the bone marrow due to the general intoxication of cancer metabolites.…”

Section: Simca Analysismentioning

confidence: 99%

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Comparative study of multivariative analysis methods of blood Raman spectra classification

Bratchenko

Lykina

et al. 2019

J Raman Spectroscopy

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The pathological state of a human body leads to altered biochemical composition of body fluids. Conventional biochemical analysis of body fluids is notable for its low‐informative value in localizing a particular pathology. As an alternative, Raman spectroscopy provides detailed evaluation of blood characteristics at the molecular level. Raman blood spectra are characterized by multicollinearity as well as by the presence of autofluorescence background and noises of different nature. Choice of a proper method for experimental data processing of blood spectra is crucial for obtaining statistically reliable information regarding a pathological process in the body. This study examines different approaches to multidimensional analysis of the various‐size Raman spectral dataset of human blood samples by a cost‐effective Raman setup in a clinical setting. To discriminate blood samples by the pathology type, statistical processing of experimental data is performed by factor analysis, logistic regression, discriminant analysis, classification tree, projection to latent structures discriminant analysis (PLS‐DA), and soft independent modeling of class analogies. Comparative analysis of the discussed multivariate methods demonstrates that the PLS‐DA method (sensitivity 0.75, specificity 0.81, and accuracy 0.76) proved to be the most effective for the classification of blood samples by cancer localization. In terms of classification for the presence of hyperproteinemia, the most efficient are the logistic regression method (sensitivity 0.89, specificity 0.99, and accuracy 0.97) and the discriminant analysis method (sensitivity 0.83, specificity 1.0, and accuracy 0.97). In general, the selected multivariate methods could serve as a reliable tool for analyzing spectral characteristics of body fluids.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Simca Analysismentioning

confidence: 99%

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Comparative study of multivariative analysis methods of blood Raman spectra classification

Bratchenko

Lykina

et al. 2019

J Raman Spectroscopy

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“…Elevated plasma levels of CRP (C reactive protein; ref. 19), IL-1 (20), , and elevated erythrocyte sedimentation rate (ESR; ref. 22,23) have all been found in metastatic cancer patients and are associated with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Differential Response of Human and Mouse Dendritic Cells to VEGF Determines Interspecies Discrepancies in Tumor-Mediated Th1/Th2 Polarity Shift

Block

Nevala

Leontovich

et al. 2011

Clinical Cancer Research

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Purpose: Metastatic cancer patients exhibit systemic dysregulation of immune polarity and are biased toward Th-2 immune responses. This is due, at least in part, to effects of VEGF on antigen presenting cell (APC) function. We therefore compared immune polarity changes in mouse models of cancer with those seen in human patients.Experimental Design: We measured plasma levels of vascular growth factors and multiple cytokines via ELISA and multiplex analysis in mice with transplantable and spontaneous tumors. We compared immune cell subsets in naive and vaccinated mice with and without tumors. We assessed cytokine immune responses by multiplex analysis. Finally, we assessed gene expression and receptor surface expression in response to VEGF in mouse and human APCs.

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“…4 C-reactive protein and SAA have greater increases in concentration in human patients with metastasis of breast carcinoma 1,12,19 and in other neoplastic diseases. 2 Tumor dissemination is described as a series of complex biologic processes that move tumor cells from the primary neoplasm to distant locations. 20 Therefore, the increased concentrations of APPs observed in cases of metastasis could be due to the direct invasion and damage of tissues by neoplastic cells or due to inflammatory mediators released during this process.…”

Section: Discussionmentioning

confidence: 99%

Serum Acute Phase Protein Concentrations in Female Dogs with Mammary Tumors

et al. 2009

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Abstract. Acute phase proteins (APPs) are proteins whose concentrations in serum change after any inflammatory stimulus or tissue damage. The aim of the current study was to evaluate 3 positive APPs (Creactive protein, serum amyloid A, and haptoglobin) and 1 negative APP (albumin) in female dogs with mammary neoplasia. Acute phase proteins were studied in 70 female dogs aged 8-12 years in the following groups: healthy (n 5 10); mammary tumors in stages I (n 5 19), II (n 5 5), III (n 5 6), IV (n 5 5), and V (n 5 7); and with mammary neoplasia plus a concomitant disease (n 5 18). In animals with mammary neoplasia, significant increases of positive APPs were only detected in those that had metastasis or a neoplasm with a diameter greater than 5 cm and ulceration. Dogs with mammary neoplasia and a concomitant disease also had high C-reactive protein concentrations. Albumin concentration was decreased in animals with metastasis and with a concomitant disease. The results of the present study indicate that the acute phase response could be stimulated in female dogs with mammary gland tumors because of different factors, such as metastasis, large size of the primary mass, and ulceration or secondary inflammation of the neoplasm.

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C-reactive protein as an acute phase protein in cancer patients

Cited by 16 publications

References 20 publications

Comparative study of multivariative analysis methods of blood Raman spectra classification

Comparative study of multivariative analysis methods of blood Raman spectra classification

Differential Response of Human and Mouse Dendritic Cells to VEGF Determines Interspecies Discrepancies in Tumor-Mediated Th1/Th2 Polarity Shift

Serum Acute Phase Protein Concentrations in Female Dogs with Mammary Tumors

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