C-Reactive Protein as a Predictor of Complicated Acute Pancreatitis: Reality or a Myth?

Ahmad, Rami Ghazi; Bhatti, Khalid M.; Ahmed, Mooyad; Malik, Kamran; Rehman, Shafiq Ur; Abdulgader, Abdulmoniem; Kausar, Ambreen; Canelo, Rubén

doi:10.7759/cureus.19265

Cited by 10 publications

(15 citation statements)

References 23 publications

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“…Perhaps no correlation was observed on d1 because CRP takes longer to peak, and no correlation may have been observed on d3 because the lipase peak was already over. Similarly, data in humans with AP indicate that CRP at admission is unpredictable of disease severity 54 . The authors discuss that CRP is usually low in humans with AP if presentation is within a few hours of the onset of clinical signs because the hepatic synthesis of CRP peaks at 36 to 50 hours in people 54 …”

Section: Discussionmentioning

confidence: 97%

“…54 The authors discuss that CRP is usually low in humans with AP if presentation is within a few hours of the onset of clinical signs because the hepatic synthesis of CRP peaks at 36 to 50 hours in people. 54 We also were interested in how pancreatic US compared with lipase measurements in a clearly defined acute setting. Data in humans suggest that it takes ≥3 episodes of AP without morphological changes in the pancreas until morphological changes are detectable.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, data in humans with AP indicate that CRP at admission is unpredictable of disease severity. 54 The authors discuss that CRP is usually low in humans with AP if presentation is within a few hours of the onset of clinical signs because the hepatic synthesis of CRP peaks at 36 to 50 hours in people. 54 We also were interested in how pancreatic US compared with lipase measurements in a clearly defined acute setting.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Progression of lipase activity and pancreatic lipase immunoreactivity in dogs hospitalized for acute pancreatitis and correlation with clinical features

Cueni

Hofer‐Inteeworn

Kümmerle‐Fraune

et al. 2022

Veterinary Internal Medicne

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Background: Lipase activity and pancreatic lipase immunoreactivity (PLI) have not been compared in dogs hospitalized for acute pancreatitis (AP). Objectives: To describe the progression of lipase activity and PLI, and correlations with clinicopathologic features in dogs with AP. Animals: Thirty-nine dogs with AP based on clinical signs and lipase activity >350 U/L (reference interval [RI], 24-108 U/L). Methods: Retrospective study. Lipase activity (LIPC Roche), PLI (SpecPL), and clinical signs were recorded daily. Admission (d1) data (clinical, laboratory, and ultrasound [US] findings), and clinical signs during hospitalization (d2-d3) were assessed for correlation with lipases. Results: Median (range) duration of clinical signs before presentation was 2 days (1-7 days). Median (range) lipase activity and PLI at d1 were 1070 U/L (range, 357-1500 U/L) and 1111 μg/L (range, 292-1500 μg/L). Strong correlation between assays at d1 (rs 0.96; P < .0001; n = 39), remained equally strong on d2 (rs 0.964; P < .0001; n = 39), and d3 (rs 0.966; P < .0001; n = 22). On d2, lipase activity and PLI were within RI in 13/39 (33%) and 18/39 (46%) of cases. Lipase activities were minimally increased (median, 124 U/L) in 5 dogs with d2 PLI <200 μg/L. On d3, 4 more dogs had normal lipase activity and PLI, and the nature and magnitude of change were always the same for both assays. Clinical signs were not associated with lipases. Only a hyperechoic mesentery, but not an US diagnosis of AP, correlated significantly with lipase activity and PLI. Conclusions and clinical importance: Lipase decreases rapidly to near or within RI within 2 days of treatment in the majority of dogs with AP. Both lipase assays yielded virtually identical results. Mesenteric echogenicity may be an early marker of AP in dogs.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Progression of lipase activity and pancreatic lipase immunoreactivity in dogs hospitalized for acute pancreatitis and correlation with clinical features

Cueni

Hofer‐Inteeworn

Kümmerle‐Fraune

et al. 2022

Veterinary Internal Medicne

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“…Some studies also shown weak association of CRP levels alone at admission and 48 h after hospital stay with complicated acute pancreatitis [ 21 ]. While modified CT severity index was considered most predictive for severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Role of serum C-reactive protein (CRP)/Albumin ratio in predicting the severity of acute pancreatitis: A retrospective cohort

Kazmi

Zafar

Zia

et al. 2022

Annals of Medicine &Amp; Surgery

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Development and validation of a predictive model for acute kidney injury in patients with moderately severe and severe acute pancreatitis

et al. 2022

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C-Reactive Protein as a Predictor of Complicated Acute Pancreatitis: Reality or a Myth?

Cited by 10 publications

References 23 publications

Progression of lipase activity and pancreatic lipase immunoreactivity in dogs hospitalized for acute pancreatitis and correlation with clinical features

Progression of lipase activity and pancreatic lipase immunoreactivity in dogs hospitalized for acute pancreatitis and correlation with clinical features

Role of serum C-reactive protein (CRP)/Albumin ratio in predicting the severity of acute pancreatitis: A retrospective cohort

Development and validation of a predictive model for acute kidney injury in patients with moderately severe and severe acute pancreatitis

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