C-reactive protein as a marker of cardiovascular disease in patients with a schizophrenia spectrum disorder treated in routine medical practice

Abstract

High CRP levels above normative were associated with both known CVD and high/very high 10-year risk of a CVD event in patients with schizophrenia, suggesting CRP could be a marker of CVD in this psychiatric disorder.

Total and differential white blood cell counts, high-sensitivity C-reactive protein, and cardiovascular risk in non-affective psychoses

“…Sicras-Mainar et al (2013) found an association between CRP levels and FGRS. However, this study did not model the FGRS as a continuous variable, but rather trichotomized cardiovascular disease risk as low (<15%), moderate (15–20%), or high/very high (>20%).…”

“…Several previous studies have also found increased FGRS in patients with schizophrenia compared to controls (Jin et al, 2011; Ratliff et al, 2013; Said et al, 2012; Sicras-Mainar et al, 2013; Tay et al, 2013; Wysokinski et al, 2012; Yazici et al, 2011). Among 689 subjects from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and matched controls from the National Health and Nutrition Examination Survey III, mean FGRS scores were significantly elevated in both males (9.4% vs 7.0%) and females (6.3% vs 4.2%) with schizophrenia (Goff et al, 2005).…”

“…This study also had a much larger sample size (n=705) than ours. A potentially important difference is that we excluded subjects taking scheduled NSAIDs, whereas Sicras-Mainar et al (2013) statistically controlled for inflammatory disease in their analysis. It is also possible that different polymorphisms in the gene for CRP moderately contributed to discordant findings.…”

“…Another recent study found that in patients with schizophrenia, CRP levels were linearly associated with 10-year cardiovascular disease risk (stratified by low, moderate, and high/very high; Sicras-Mainar et al, 2013). However, total and differential WBC counts have not been explored as a predictor of cardiovascular disease risk in schizophrenia.…”

The relationships between low grade inflammation, demographic and clinical characteristics in patients with obsessive compulsive disorder

“…A level greater than 3 mg/l was considered outside the normal range for the normative values or high for this technique in our laboratory, and is consistent with values considered elevated according to the American Heart Association and the Centers for Disease Control and Prevention (AHA/CDC) statement on markers of inflammation and cardiovascular disease. 25,26 Two groups were compared with regard to age, gender, BMI, smoking status, education, place of residence and socioeconomic status. In addition, clinical variables were compared between patients with normal and elevated levels of CRP.…”