C‐reactive protein as a candidate biomarker in fibrotic interstitial lung disease

Cottin, Vincent; Valenzuela, Claudia

doi:10.1111/resp.14666

Cited by 2 publications

(1 citation statement)

References 29 publications

(41 reference statements)

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“…CRP is an acute-phase protein primarily synthesized in liver hepatocytes and plays a critical role in inflammation response ( 14 – 17 ). When the body is invaded by pathogens such as bacteria, fungi, parasites or subjected to inflammatory stimuli, as well as after tissue damage caused by trauma and progressive cancer, the plasma concentration of CRP can increase rapidly within 6–8 hours and reach the peak in about 48 hours, rising 1000-fold from the basal level ~ 0.5 μg/ml ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein: structure, function, regulation, and role in clinical diseases

Zhou,

Tang,

et al. 2024

Front. Immunol.

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C-reactive protein (CRP) is a plasma protein that is evolutionarily conserved, found in both vertebrates and many invertebrates. It is a member of the pentraxin superfamily, characterized by its pentameric structure and calcium-dependent binding to ligands like phosphocholine (PC). In humans and various other species, the plasma concentration of this protein is markedly elevated during inflammatory conditions, establishing it as a prototypical acute phase protein that plays a role in innate immune responses. This feature can also be used clinically to evaluate the severity of inflammation in the organism. Human CRP (huCRP) can exhibit contrasting biological functions due to conformational transitions, while CRP in various species retains conserved protective functions in vivo. The focus of this review will be on the structural traits of CRP, the regulation of its expression, activate complement, and its function in related diseases in vivo.

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Section: Introductionmentioning

confidence: 99%