C‐reactive protein and systemic lupus erythematosus

Gaitonde, Shilpa; Samols, David; Kushner, Irving

doi:10.1002/art.24316

Cited by 106 publications

(98 citation statements)

References 93 publications

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“…[2][3][4] Although autoantibodies, complement proteins, blood cell counts and erythrocyte sedimentation rate (ESR) can be helpful markers of diagnosis, prognosis, and/or degree of ongoing inflammation, distinction of disease activity from irreversible organ damage remains a challenge. 5 C-reactive protein (CRP) is usually a reliable marker of systemic inflammation, but this is not the case in SLE 6,7 or viral infections 8 probably due to interferon alpha (IFN dependent inhibition of hepatic CRP production. 9 Other biomarkers may reflect specific organ involvements, most notably lupus nephritis which is often mirrored by raised levels of autoantibodies against double-stranded (ds) DNA, nucleosomes and/or complement protein (C) 1q.…”

Section: Introductionmentioning

confidence: 99%

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Enocsson

Wetterö

Skogh

et al. 2013

Translational Research

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Compared to healthy controls, serum suPAR levels were significantly elevated in SLE patients. No association was recorded regarding suPAR levels and SLE disease activity in cross-sectional or consecutive samples. However, a strong association was observed between suPAR and SDI (p<0.0005). Considering distinct SDI domains, renal, neuropsychiatric, ocular, skin and peripheral vascular damage had significant impact on suPAR levels.This study is the first to demonstrate an association between serum suPAR and irreversible organ damage in SLE. Further studies are warranted to evaluate suPAR and other biomarkers as predictors of evolving organ damage.

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Section: Introductionmentioning

confidence: 99%

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Enocsson

Wetterö

Skogh

et al. 2013

Translational Research

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“…Moreover, although serum levels of CRP usually go in parallel with the disease activity in inflammatory states, the results from this point in SLE are inconclusive, being suggested that this autoimmune disease could be an exception (50). In this regard, while some authors have reported moderate levels of CRP (2.1 mg/l) in lupus subjects (51), others have associated this pathology with a high increase (15-16 mg/l) in this acute-phase protein (12).…”

Section: Discusionmentioning

confidence: 99%

Microbiota and oxidant-antioxidant balance in systemic lupus erythematosus

et al. 2017

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ResumenBackground: Systemic lupus erythematosus (SLE) is a chronic infl ammatory disease of autoimmune nature, in which oxidative stress is implicated. Aim: Compare the concentrations of dietary and blood antioxidants, as well as gut microbiota, with serum malondialdehyde (MDA) and C reactive protein (CRP) in 21 subjects suffering from non-active systemic lupus erythematosus (SLE) and 21 age and gender-matched controls. Methods: General biochemical parameters and CRP were determined by enzymatic methods: copper, zinc and selenium by inductively coupled plasma mass spectrometry (ICP-MS), MDA and total antioxidant capacity (TAC) by spectrophotometric methods, gut microbiota by metagenomic analyses and dietary intake by means of food frequency questionnaire. Results: No signifi cant differences were found in diet between lupus patients and the control group, with the exception of trans fatty acids intake, which was higher in patients. In addition, higher concentration of serum copper and lower of zinc in SLE were found. Serum copper was positively associated with CRP and also, this protein with the proportion of Lentisphaerae, Proteobacteria and Verrucomicrobia in feces. Moreover, MDA levels displayed inverse correlations with the Cyanobacteria and Firmicutes groups, while Actinobacteria showed a positive association. The lupus subjects with presence of anti-SSA/Ro were related to higher levels of serum zinc. Conclusion: These results could be useful in the future to go deeper into the understanding of this complex disease. AbstractIntroducción: el lupus eritematoso sistémico es una enfermedad infl amatoria crónica en la que está implicado el estrés oxidativo. Objetivo: evaluar la concentración de antioxidantes de la dieta y sanguíneos, así como de la microbiota sobre las concentraciones de malondialdehído y proteína C reactiva en 21 pacientes de lupus y 21 controles pareados por edad y sexo. Métodos: los parámetros bioquímicos de rutina y proteína C reactiva se determinaron a través de métodos enzimáticos: cobre, zinc y selenio por espectrometría de masas, malondialdehído y capacidad antioxidante total por métodos espectrofotométricos, la microbiota fecal por técnicas metagenómicas y la dieta a través de cuestionarios de frecuencia de consumo. Resultados: no se han observado diferencias en la dieta en los pacientes con lupus respecto al grupo control, excepto en la ingesta de ácidos grasos trans, siendo mayor en el grupo de lupus. En estas pacientes se observaron mayores niveles circulantes de cobre y menores de zinc. La concentración de cobre en suero se relacionó directamente con los niveles de proteína C reactiva y esta proteína, a su vez, con la proporción de Lentisphaerae, Proteobacteria y Verrucomicrobia en heces. Además, mientras que los niveles de malondialdehído se asociaban inversamente con la proporción de Cyanobacteria y Firmicutes, con Actinobacteria se encontró una correlación positiva. La presencia de anti-SSA/Ro en lúpicas se relaciona con mayores concentraciones de zinc. Conclusió...

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“…Ukrywanie antygenów przed układem immunologicznym i przyspieszenie ich usuwania przez pentraksyny zapobiega autoimmunizacji. Uważa się, że niedobór CRP, SAP i PTX3 w toczniu rumieniowatym układowym odgrywa rolę w rozwoju i progresji choroby [53,54]. W związku z tym, że PTX3 jest syntetyzowana lokalnie w miejscu uszkodzenia i stanu zapalnego, szczególnie w obrębie naczyń, pojawiają się doniesienia o możliwości jej wykorzystania jako markera ich uszkodzenia [55].…”

Section: Pentraksynaunclassified

Significance of selected inflammatory factors in metabolic disorders in association with psoriasis

Kiluk¹,

Baran²,

Flisiak³

2017

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C‐reactive protein and systemic lupus erythematosus

Cited by 106 publications

References 93 publications

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Microbiota and oxidant-antioxidant balance in systemic lupus erythematosus

Significance of selected inflammatory factors in metabolic disorders in association with psoriasis

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