C‐reactive protein and leucocyte activation in psoriasis <i>vulgaris</i> according to severity and therapy

Coimbra, Susana; Oliveira, Hugo; Reis, Flávio; Belo, Luı́s; Rocha, Susana; Quintanilha, Alexandre; Figueiredo, Américo; Teixeira, Frederico; Castro, Elisabeth; Rocha‐Pereira, Petronila; Santos-Silva, Alice

doi:10.1111/j.1468-3083.2009.03527.x

Cited by 119 publications

(165 citation statements)

References 39 publications

(57 reference statements)

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“…The findings of present study correlate well with findings of previous studies -Pereira et al (2004) [5], Coimbra et al (2009) [15], Yiu et al (2011) [16] and Lucy Piper et al (2012) [4].…”

Section: Increased C -Reactive Protein Levelssupporting

confidence: 83%

Serum biomarkers for diagnosis and assessment of severity in psoriasis

B¹,

Kumar²

2016

Int J of Biomed & Adv Res

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“…The findings of present study correlate well with findings of previous studies -Pereira et al (2004) [5], Coimbra et al (2009) [15], Yiu et al (2011) [16] and Lucy Piper et al (2012) [4].…”

Section: Increased C -Reactive Protein Levelssupporting

confidence: 83%

Serum biomarkers for diagnosis and assessment of severity in psoriasis

B¹,

Kumar²

2016

Int J of Biomed & Adv Res

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“…31 An association between increased CRP levels, neutrophil activation, chronic systemic inflammation and risk for cardiovascular diseases has already been reported in the literature. 32,33 Spesifically NLR and serum CRP levels, which were found to be elevated in CSU patients in the present study, have shown to be prognostic and predictor markers in cardiovascular diseases. What we discuss here is, if the patients with CSU without any systemic, inflammatory or autoimmune diseases might be under the risk of development of cardiovascular diseases in the future.…”

Section: Discussionmentioning

confidence: 77%

Serum C-Reactive Protein, Neutrophil-Lymphocyte Ratio and Uric Acid Levels in Chronic Spontaneous Urticaria

Karabay¹,

Çerman²,

Altunay³

2016

Turkiye Klinikleri J Dermatol

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Recent studies implicate the role of inflammatory responses in chronic spontaneous urticaria (CSU). The purpose of this study was to analyse the levels of neutrophil-lymphocyte ratio (NLR), serum C-reactive protein (CRP) and uric acid levels in CSU patients, and to investigate the relationship between these inflammatory parameters and disease activity. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 100 people, consisting of 50 chronic urticaria patients and 50 healthy controls, who have no systemic disease, inflammatory, infectious or autoimmune disease, malignancy, were included in the study. R Re es su ul lt ts s: : NLR and serum CRP levels were significantly higher in patients with CSU than in healthy controls (p< 0.001, p< 0.001, respectively). The levels of uric acid did not show a statistically significant difference between CSU patients and controls (p= 0.359). A significant positive correlation was found between NLR and CRP in patients with CSU (p= 0.001, r= 0.442).When CSU patients were evaluated according to disease severity, serum CRP levels were significantly higher in patients with severe CSU than in patients with mild-moderate CSU (p= 0.038). C Co on nc cl lu us si io on n: : Several biomarkers have been studied in systemic diseases to determine the inflammatory process ongoing and the relationship between these markers and disease activity has been investigated. It can be concluded that CRP and NLR can be used to assess the inflammatory status in CSU and may be useful parameters during the follow-up of these patients. It is known that NLR and CRP are diagnostic and prognostic markers of cardiovascular diseases. Elevated values of NLR and CRP may demand caution regarding cardiovascular comorbidities that may accompany chronic urticaria.K Ke ey y W Wo or rd ds s: : C-reactive protein; neutrophils; uric acid; urticaria Ö ÖZ ZE ET T A Am ma aç ç: : Son dönemde yapılan çalışmalarda kronik spontan ürtikerde (KSÜ) inflamatuar yanıtın üzerinde durulmaktadır. Bu çalışmanın amacı KSÜ hastalarında nötrofil-lenfosit oranı (NLO), serum C-reaktif proteini (CRP) ve ürik asid düzeylerini belirlemek ve bu inflamatuar parametreler ile hastalık aktivitesi arasında ilişki olup olmadığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Herhangi bir sistemik hastalığı, inflamatuar veya infeksiyöz hastalığı, malignitesi, otoimmün hastalığı olmayan 50 kronik ürtiker hastası ve 50 sağlıklı kontrol olmak üzere toplam 100 kişi çalışmaya dahil edildi. B Bu ul lg gu ul la ar r: : NLO ve CRP düzeyleri KSÜ hastalarında sağlıklı kontrollere göre anlamlı olarak daha yüksekti (p<0,001, p<0,001, sırasıyla). Ürik asid düzeyleri açısından KSÜ hastaları ve sağlıklı kontroller arasında anlamlı bir fark izlenmedi (p=0,359). KSÜ hastalarında NLO ve CRP arasında anlamlı pozitif korelasyon mevcuttu (p=0,001, r=0,442). KSÜ hastaları hastalık şiddetine göre incelendiğinde serum CRP düzeyleri şiddetli KSÜ hastalarında hafif-orta şiddetli KSÜ h...

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“…Since etanercept does not cross BBB it is likely that modulation of circulating inflammatory markers was responsible for the changes (Krishnadas, 2010). While it is possible that the reduction in 5-HTT availability was the result of improvement in clinical symptoms of psoriasis/arthritis, reduction in CRP -a marker of clinical inflammatory activity -was not associated with the reduction in 5-HTT (Beygi et al, 2013;Coimbra et al, 2009;Strober et al, 2008). In addition, clinical response rates to etanercept are around 50% and peak at 4 to 6 months following therapy.…”

Section: Discussionmentioning

confidence: 90%

Circulating tumour necrosis factor is highly correlated with brainstem serotonin transporter availability in humans

Krishnadas

Nicol

Sassarini

et al. 2016

Brain, Behavior, and Immunity

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Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans, Brain, Behavior, and Immunity (2015), doi: http://dx.doi.org/ 10. 1016/j.bbi.2015.08.005 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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C‐reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy

Abstract: We propose CRP as a useful marker of psoriasis severity that could be used to monitor psoriasis and its treatment, and, together with PASI and elastase, could also be used as a global index of severity.

Cited by 119 publications

References 39 publications

Serum biomarkers for diagnosis and assessment of severity in psoriasis

Serum biomarkers for diagnosis and assessment of severity in psoriasis

Serum C-Reactive Protein, Neutrophil-Lymphocyte Ratio and Uric Acid Levels in Chronic Spontaneous Urticaria

Circulating tumour necrosis factor is highly correlated with brainstem serotonin transporter availability in humans

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