C-reactive protein and features of metabolic syndrome in Brazilian women with previous gestational diabetes

Ferraz, Tânia B.; Motta, Rosa S.; Ferraz, Camila; Capibaribe, Diego Moreira; Forti, Adriana Costa e; Chacra, Antônio Roberto

doi:10.1016/j.diabres.2007.01.025

Cited by 23 publications

(22 citation statements)

References 46 publications

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“…CRP, an inflammatory agent common in numerous pathologic conditions, has been associated with metabolic abnormal states such as insulin resistance, hyperglycemia, and T2DM [31, 34–36], while it also appears to be associated with central obesity [44, 46]. …”

Section: Other Mediators Of Inflammation In Pgdmmentioning

confidence: 99%

“…As concerns pGDM, there is some evidence that women with a history of prior GDM have postpartum increased CRP that manifests chronic subclinical inflammation [40–46]. Increased CRP levels in women with pGDM, which have also been related to metabolic syndrome [45], have been reported in several studies [43–46].…”

Section: Other Mediators Of Inflammation In Pgdmmentioning

confidence: 99%

“…Increased CRP levels in women with pGDM, which have also been related to metabolic syndrome [45], have been reported in several studies [43–46]. …”

Section: Other Mediators Of Inflammation In Pgdmmentioning

confidence: 99%

“…Macrophages secrete cytokines which activate the subsequent secretion of inflammation mediating agents, specifically interleukin-6 (IL-6) and C-reactive protein (CRP). Moreover, other molecules such as Plasminogen Activator Inhibitor 1 (PAI-1) and sialic acid lead to dysregulations of metabolism, hyperglycemia, insulin resistance, and, finally, overt T2DM [31, 34–46]. …”

Section: Introductionmentioning

confidence: 99%

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Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus

Vrachnis

Belitsos

Sifakis

et al. 2012

International Journal of Endocrinology

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Previous Gestational Diabetes Mellitus (pGDM) is a common condition and has been associated with future development of Type 2 Diabetes Mellitus (T2DM) and Metabolic Syndrome (MS) in women affected. The pathogenesis and risk factors implicated in the development of these conditions later in the lives of women with pGDM are not as yet fully understood. Research has recently focused on a group of substances produced mainly by adipose tissue called adipokines, this group including, among others, adiponectin, leptin, Retinol-Binding Protein-4 (RBP-4), and resistin. These substances as well as other inflammatory mediators (CRP, IL-6, PAI-1, TNF-α) seem to play an important role in glucose tolerance and insulin sensitivity dysregulation in women with pGDM. We summarize the data available on the role of these molecules.

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Section: Other Mediators Of Inflammation In Pgdmmentioning

confidence: 99%

Section: Other Mediators Of Inflammation In Pgdmmentioning

confidence: 99%

“…Increased CRP levels in women with pGDM, which have also been related to metabolic syndrome [45], have been reported in several studies [43–46]. …”

Section: Other Mediators Of Inflammation In Pgdmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus

Vrachnis

Belitsos

Sifakis

et al. 2012

International Journal of Endocrinology

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“…In women with previous gestational diabetes, the risk of developing type 2 DM within 5-16 years varies between 17-63% (4). The relationship between type 2 DM and cardiovascular disease has been investigated; there is an extensive number of studies (5)(6)(7)(8) assessing preclinical indicators of the atherosclerotic process that can precede the development of type 2 diabetes. However, the cardiovascular risk in women with pregnancies complicated by gestational diabetes is scarce.…”

mentioning

confidence: 99%

Effect of Human Gestational Diabetes Mellitus on Arterial Stiffness

İnci¹

2014

Acta Endo (Buc)

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Background. The present study aims to evaluate the parameters for aortic stiffness by comparing gestational diabetes mellitus (GDM) with a healthy control group via transthoracic echocardiography.Methods. This was a cross-sectional study involving monitoring of 62 pregnant women (33 with GDM and 29 with uncomplicated pregnancy as controls) during the third trimester. The aortic strain, aortic distensibility, and aortic stiffness values were measured via transthoracic echocardiography. Measurements of GDM group were repeated after 6 months.Results. Blood pressure levels, heart rate, and basic echocardiography were similar in both groups, but BMI was significantly higher in the GDM group (p <0.001). Whereas, aortic strain and distensibility were significantly lower in the GDM group (p <0.001). Aortic stiffness index was significantly higher in the GDM group (p <0.001). Aortic stiffness parameters did not exhibit any significant difference between the insulin-receiving GDM group and the diet-controlled GDM group. Postprandial glucose levels were correlated positively with the aortic stiffness index (p=0.04) andnegatively with the level of aortic strain (p<0.01) and distensibility (p=0.03). The aortic stiffness in normoglycemic postpartum group at 6 th month showed a significant improvement (p<0.001); but not in hyperglycemic postpartum group.Conclusion. Arterial stiffness was increased in women with GDM compared to the control group. A correlation between postprandial glucose and arterial stiffness was found. The aortic stiffness can be affected irreversibly from increased clinical and subclinical levels of glucose in postpartum period.

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Current literature in diabetes

2008

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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C-reactive protein and features of metabolic syndrome in Brazilian women with previous gestational diabetes

Cited by 23 publications

References 46 publications

Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus

Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus

Effect of Human Gestational Diabetes Mellitus on Arterial Stiffness

Current literature in diabetes

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