C-Reactive Protein and Body Mass Index Predict Outcome in End-Stage Respiratory Failure

Cano, Noël; Pichard, Claude; Roth, Hubert; Court-Fortuné, Isabelle; Cynober, Luc; Gerard-Boncompain, M.; Cuvelier, A.; Laaban, J. P.; Melchior, Jean‐Claude; Raphaël, Jean-Claude; Pison, Christophe

doi:10.1378/chest.126.2.540

Cited by 115 publications

(82 citation statements)

References 31 publications

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“…Wilson et al showed elevated levels of systemic inflammatory markers (WBC count, ESR and CRP) in bronchiectasis; these inflammatory parameters were significantly correlated with HRCT scores (15). In a study done among patients with diseases that cause end-stage respiratory failure, bronchiectasis patients had higher CRP levels with respect to other diseases that cause respiratory failure (21). CRP levels were also independently associated with mortality in this study (21).…”

supporting

confidence: 58%

“…In a study done among patients with diseases that cause end-stage respiratory failure, bronchiectasis patients had higher CRP levels with respect to other diseases that cause respiratory failure (21). CRP levels were also independently associated with mortality in this study (21). In addition, it has been shown that systemic inflammation, as reflected by elevated ESR and CRP levels, is related with rapid decline in FEV 1 in patients with bronchiectasis (20).…”

supporting

confidence: 51%

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Does airway colonization cause systemic inflammation in bronchiectasis?

Çöplü²

2011

Tuberk Toraks

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supporting

confidence: 58%

supporting

confidence: 51%

Does airway colonization cause systemic inflammation in bronchiectasis?

Çöplü²

2011

Tuberk Toraks

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“…Indeed, some studies reported statistical associations between weight loss in COPD and the raised serum levels of TNF-a and other cytokines [26][27][28][29]. Other studies indicated that both nutritional depletion and inflammation had a negative prognostic value in COPD [30].…”

Section: Copd As a Putative Cause Of Anaemia Of Chronic Diseasementioning

confidence: 99%

The potential impact of anaemia of chronic disease in COPD

Similowski

Agustí²,

MacNee³

et al. 2006

European Respiratory Journal

152

107

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Anaemia of chronic disease (ACD), with chronically low levels of circulating haemoglobin, is an immune driven abnormality that occurs in many inflammatory diseases, and also in chronic heart failure. Although chronic obstructive pulmonary disease (COPD) is ''traditionally'' associated with polycythaemia, the systemic inflammation that is now recognised as a feature of COPD makes it a possible cause of ACD. If present in COPD, anaemia could worsen dyspnoea and limit exercise tolerance.Preliminary evidence suggests that anaemia in COPD patients may be more prevalent than expected, concerning 10-15% of patients suffering from severe forms of the disease. A database study conducted in 2,524 COPD patients being prescribed long-term oxygen therapy has shown that a low haematocrit is a strong predictor of survival in this population, before body mass index, and is associated with more hospitalisations and a longer cumulative duration of hospitalisation. COPD patients with low haemoglobin levels have a poorer prognosis than COPD patients with normal haemoglobin levels in the event of acute gastrointestinal bleeding or after elective aneurysm repair. Raising haemoglobinaemia through transfusion decreases minute ventilation and work of breathing in COPD patients.These preliminary evidences point to the need to study the prevalence of anaemia, and its physiological and clinical impact in chronic obstructive pulmonary disease. When this body of knowledge is available, the question of the putative benefits of raising haemoglobinaemia in chronic obstructive pulmonary disease will have to be addressed.

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“…It is also observed in other end-stage pulmonary diseases in which it is similarly associated with shorter long-term survival (Cano et al, 2002(Cano et al, , 2004. However, the knowledge of the prevalence of malnutrition or altered body composition in these diseases is scarce.…”

Section: Introductionmentioning

confidence: 99%

Nutritional depletion and its relationship to respiratory impairment in patients with chronic respiratory failure due to COPD or restrictive thoracic diseases

et al. 2007

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Objective: While malnutrition, especially fat-free mass index (FFMI), is a predictor for mortality in chronic obstructive pulmonary disease (COPD), less information on prevalence and mechanisms is available in patients with chronic respiratory failure (CRF) due to restrictive thoracic diseases (RTD). Design and setting: Cross-sectional study of patients consecutively admitted to an in-patient primary pulmonary centre. Subjects: One hundred and thirty-two patients (30% RTD; 70% COPD) with CRF and intermittent non-invasive positive pressure ventilation. Interventions: Malnutrition was quantified by bioelectrical impedance analysis or body mass index (BMI), and its relationship to laboratory, lung function, inspiratory muscle and blood gas parameters and 6-min walking distance (6-MWD) was assessed. Results: Malnutrition in terms of BMIo20 kg/m 2 occurred in 16.1% of patients with COPD but none of those with RTD. FFMIo17.4 (o15.0 in female patients) kg/m 2 was found in 35.4 and 30.7%, respectively. FFMI was correlated with airway obstruction (sR aw , r ¼ À0.50; FEV 1 /VC, r ¼ À0.28; Pp0.01 each) and lung hyperinflation (intrathoracic gas volume, r ¼ À0.41; total lung capacity (TLC), r ¼ À0.50; Pp0.001 each) in COPD, and with lung restriction in RTD (TLC, r ¼ 0.40; P ¼ 0.011). Furthermore, malnourished patients showed a higher inspiratory load (P 0.1 ) and reduced 6-MWD in both groups. In COPD, only hyperinflation and P 0.1 were independently related to FFMI. Conclusions: Malnutrition as indicated by low FFMI was similarly prevalent in patients with CRF and COPD or RTD, but inadequately represented by BMI. The correlations between lung function impairments specific for the disease and FFMI emphasized the link between malnutrition and respiratory mechanical load irrespective of its aetiology.

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C-Reactive Protein and Body Mass Index Predict Outcome in End-Stage Respiratory Failure

Cited by 115 publications

References 31 publications

Does airway colonization cause systemic inflammation in bronchiectasis?

Does airway colonization cause systemic inflammation in bronchiectasis?

The potential impact of anaemia of chronic disease in COPD

Nutritional depletion and its relationship to respiratory impairment in patients with chronic respiratory failure due to COPD or restrictive thoracic diseases

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