C-reactive protein and angiographic characteristics of stable and unstable coronary artery disease: Data from the prospective PREVEND cohort

Geluk, Christiane A.; Post, Wendy J.; Hillege, Hans L.; Tio, René A.; Tijssen, Jan G.P.; Dijk, Rene B. van; Dijk, W.A.; Bakker, Stephan J. L.; Jong, Paul E. de; Gilst, Wiek H. van; Zijlstra, Felix

doi:10.1016/j.atherosclerosis.2006.11.013

Cited by 43 publications

(31 citation statements)

References 36 publications

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“…Both pathways compromise cardiovascular integrity; they may trigger the progression and destabilization of inflamed vulnerable arterial plaques and subsequently lead to adverse cardiovascular events [23]. Although there is a lack of consensus on the implementation of blood level of inflammatory markers/mediators in everyday clinical practice, accumulating evidence suggests that some of these markers, especially CRP, may be of value as a clinical tool for assessment of cardiovascular risk or treatment efficacy [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Acute effect of sildenafil on inflammatory markers/mediators in patients with vasculogenic erectile dysfunction

Vlachopoulos

Ioakeimidis

Rokkas

et al. 2015

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Acute effect of sildenafil on inflammatory markers/mediators in patients with vasculogenic erectile dysfunction

Vlachopoulos

Ioakeimidis

Rokkas

et al. 2015

International Journal of Cardiology

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“…Furthermore, the binding of advanced glycosylation end-product is associated with overproduction of inflammatory mediators like CRP [69]. Increased CRP level has been shown to be significantly linked with the instability of plaque [70,71]. This explains why that after adjustifying CRP, there is no significant association between HbA1c and the severity of CAD.…”

Section: Fig 2: Correlation Between Different Metabolic Parameters Amentioning

confidence: 84%

Clinical Significance of Procalcitonin and C-Reactive Protein in the Prediction of Cardiovascular Complications in Patients With Type 2 Diabetes Mellitus

Ahmed

Shousha

El-mezayen

et al. 2017

Asian J Pharm Clin Res

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Objective: This work was delineated to assess procalcitonin (PCT) and C-reactive protein (CRP) as prognostic markers for cardiovascular complication in type 2 diabetic patients.Methods: Forty diabetic patients without cardiovascular disease (CVD), 40 diabetic patients with CVD, and 20 healthy control counterparts were participated in this study. Serum PCT and CRP levels were assayed and correlated with metabolic parameters. Receiver operating characteristic (ROC) curve analysis was done for each biochemical marker. Results:The mean level of PCT was 707.17±99.19 ng/l in diabetic patients versus 881.30±123.56 ng/l for the cardio-diabetic patients (p<0.0001). The mean value of CRP was 34.43±17.27 mg/l in diabetic patients versus 50.32±20.19 mg/l for the cardio-diabetic patients (p=0.0003). PCT levels were significantly amplified in the cardio-diabetic patients with increasing CRP, triglycerides (TG), fasting blood glucose (FBG), and cholesterol (p=0.004, 0.0005, 0.002, and 0.01, respectively). CRP levels were significantly enhanced in the cardio-diabetic patients with increasing TG, FBG, cholesterol, and microalbumin (p=0.002, 0.047, 0.003, and 0.001 respectively). ROC curve analysis for PCT and CRP revealed that the area under curve (AUC) was 0.878 and 0.727, respectively. These findings indicate the good validity of the above biomarkers especially PCT as a prognostic marker for cardiovascular complication in type 2 diabetic patients. Conclusion:This study evidences the usefulness of measuring serum levels of PCT and CRP in diagnosis of cardiovascular complication in type 2 diabetic patients.

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“…Smokers also have higher levels of circulating inflammatory markers such as Creactive protein (CRP), IL-6, TNF-, soluble-intercellular adhesion molecule-1 (sICAM-1), and fibrinogen than non-smokers [76][77][78][79]. The population-based Prevention of Renal and Vascular Endstage Disease (PREVEND) study, a 6-year follow-up study, has clearly established the link between systemic inflammatory markers and cardiovascular risk by demonstrating that increased levels of highly sensitive CRP were associated with high-risk angiographic features and progression of plaque during follow-up [80]. Activated mast cells are abundant in human atherosclerotic plaques and contribute to the immune-mediated plaque destabilization.…”

Section: Smoking and Coronary Plaque Stabilitymentioning

confidence: 97%

Nicotine Addiction and Coronary Artery Disease: Impact of Cessation Interventions

Gaemperli¹,

Liga²,

Bhamra-Ariza³

et al. 2010

CPD

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Cigarette smoking is the leading preventable cause of death worldwide, and a considerable proportion of smoking-related fatalities are attributable to coronary artery disease (CAD). The detrimental effects of smoking span all stages in the development of CAD ranging from the early functional alterations in the endothelium and the microcirculation to the late clinicopathological manifestations of atherosclerotic plaques. Smoking results in the generation of free radicals and increased oxidative stress which plays a central role in the pathogenetic mechanisms leading to atherosclerotic disease. It causes reduced nitric oxide bioavailability and lipid peroxidation which are crucial initial steps of plaque formation. Furthermore, smoking enhances leukocyte and platelet activation and promotes local and systemic inflammation, which contribute to plaque progression and maturation. Finally, alterations in fibrinolytic and prothrombotic factors create a pro-thrombogenic environment which harbours the risk of plaque rupture and thrombosis. In smokers, the cessation of smoking is the most important intervention for cardiovascular risk reduction. Total mortality can be reduced by 36% which is comparable to established modern secondary preventive therapies. Nonetheless, non-aided cessation attempts are notoriously poor with a success rate of less than 10%. Patient counselling and pharmacological therapies are important aides for smoking cessation and can improve success rates by two to threefold. However, there is still need for improved strategies of smoking cessation to reduce the high socioeconomic impact of smoking.

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C-reactive protein and angiographic characteristics of stable and unstable coronary artery disease: Data from the prospective PREVEND cohort

Cited by 43 publications

References 36 publications

Acute effect of sildenafil on inflammatory markers/mediators in patients with vasculogenic erectile dysfunction

Acute effect of sildenafil on inflammatory markers/mediators in patients with vasculogenic erectile dysfunction

Clinical Significance of Procalcitonin and C-Reactive Protein in the Prediction of Cardiovascular Complications in Patients With Type 2 Diabetes Mellitus

Nicotine Addiction and Coronary Artery Disease: Impact of Cessation Interventions

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