C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants

Serum levels and genotype distribution of α1-antitrypsin in the general population

“…Although 70–80% of the variation in total AAT serum concentration is explained by the Pi type (after age and sex adjustment),23 other factors can influence variation 13. Since AAT is an acute-phase reactant, inflammatory status may increase the serum level of AAT 11 13 24. As shown in table E2, when SAPALDIA subjects were stratified according to the presence or absence of an inflammatory condition, most SERPINA1 genotypes showed even narrower ranges, particularly those with CRP <8 mg/litre.…”

The Immunoregulation Effect of Alpha 1-Antitrypsin Prolong β-Cell Survival after Transplantation

“…These mediators were reported to cause islet graft failure via antigen-independent inflammation and correlate with poor transplant outcome [18]–[20].Thus, the ability of hAAT to diminish inflammatory mediators in the graft tissue may provide the basis for the diminished alloimmune response and prolonged islet graft survival. C reactive protein (CRP) has been proposed as a marker of systemic inflammation [21]. CRP and other inflammatory factors are closely related, once the inflammation reaction initiated, CRP level increased.…”

Genetic variation in C‐reactive protein in ethnic Chinese population in Taiwan

“…Previous studies showed that single‐nucleotide polymorphisms (SNPs) in the CRP gene were associated with the baseline hs‐CRP concentrations in different populations . However, the results were not consistent in a recent study of southern Europeans . Given that the normal hs‐CRP level could be varied in different ethnic populations and may be lower in oriental than western people, it is then interesting to know the genetic contribution to serum hs‐CRP level in different populations such as the oriental cohort.…”