C‐reactive protein: An independent predictor for dedifferentiated chondrosarcoma

Abstract

Dedifferentiated chondrosarcoma is a rare primary bone malignancy with a very poor prognosis. The aim of the study was to identify pretreatment serum markers as prognostic factors for the overall survival (OS) of patients with dedifferentiated chondrosarcoma. We retrospectively reviewed 33 patients with histologically confirmed dedifferentiated chondrosarcoma treated at our department from 1977 to 2015. Kaplan‐Meier estimation, uni‐ and multivariable Cox proportional hazard model were performed to evaluate the association between serum markers such as the C‐reactive protein and OS. In univariable analysis, CRP was strongly associated with OS (HR 1.35; 95%CI 1.13–1.61; p = 0.001). This association prevailed after adjustment for AJCC tumor stage (HR 1.31; 95%CI 1.02–1.57; p = 0.031) in multivariable analysis. In conclusion, our data gave evidence that baseline CRP is an independent predictor for OS in patients with dedifferentiated chondrosarcoma. CRP could be exploited for the clinical prediction of this disease in the future. © 2018 The Authors. Journal of Orthopaedic Research® Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 36:2797–2801, 2018.

Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution

“…DDCS is slightly more frequent in males. Patients with DDCS are older than those with conventional lesions, with a mean age of around 60 years (range: 15-90 years) [1,3,[6][7][8][9]. e most common sites were the femur and pelvis, followed by humerus and scapula [1,3,6].…”

Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases

“…Pelvic location, increased age, size (tumor lesion greater than 8 cm), and pathological fracture have also been found or confirmed to be prognostic factors [ 18 , 22 , 23 ]. After investigating C-reactive protein in predicting overall survival of patients with dedifferentiated chondrosarcoma, Nemecek et al [ 24 ] found that elevated C-reactive protein was significantly associated with worse overall survival and was an independent prognostic factor for dedifferentiated chondrosarcoma.…”

Scapula chondrosarcoma

“…[27] Risk factors, such as grading, metastatic disease, age, and location, significantly influence overall survival. [28] In a recent study, [29] CRP was exploited for clinical prediction of this disease. Owing to the possibility of local recurrence and metastasis, resected patients should undergo routine lifelong surveillance, consisting of clinical and radiological examination every 3–6 months for the first 5 years and annually thereafter for a minimum of 15 years.…”