C-Reaction Protein and the Severity of Intracerebral Hemorrhage: A Study from Chinese Stroke Center Alliance

Abstract

Background: Intracerebral hemorrhage (ICH) has a high mortality and morbidity in the world. C-Reaction Protein (CRP) has been demonstrated to be an independent risk factor and could predict the severity and outcome of ischemic stroke. In our study, we aimed to find out the relationship between CRP levels and the severity and outcome of patients with ICH. Methods: This study comes from the Chinese Stroke Center Alliance (CSCA). Patients' basic characteristics and laboratory examination results, including the concentration of CRP were taken from August 2015 to July 2019. Chi-square test and Logistic regression were used to analyze the relationship between different CRP levels and clinical outcome. Results: A total of 9589 patients with acute ICH were enrolled in our study. In the logistic regression analysis, we found out that high CRP level is an independent risk factor for the prevalence of severe ICH and in-hospital death. After adjusting sex, age and other relevant stroke risk factors, the difference still exists (Severe ICH: odd ratio (OR) (95% confidence interval (CI) = 1.14 (1.04-1.26), P = 0.0076 for CRP between 3-10mg/l group and 1.64 (1.46-1.84), P<0.0001 for CRP>10mg/l group. In-hospital death: OR(95%CI)= 2.03(1.39-2.95), P=0.0002 for CRP>10mg/l group). Conclusions: High CRP level was independently associated with poorer clinical outcome and higher in-hospital death in patients with ICH.

A Prospective Cohort Study of Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 as a Serologic Marker in Relation to Severity and Functional Outcome of Acute Intracerebral Hemorrhage

“…In addition, serum ITIH4 levels are inversely correlated with serum TNF-α, interleukin-1beta, interleukin-6 and interleukin-17A in humans with acute ischemic stroke. 28 C-reactive protein (CRP) is an acute-phase reaction protein, and its levels can reflect the extent of the systemic inflammatory 34 Our study showed that serum C-reactive protein levels were independently inversely correlated with serum ITIH4 levels in the cohort of patients with ICH. These data suggest that ITIH4 may be an anti-inflammatory factor with protective functions in acute brain injury.…”

g.ridge: An R Package for Generalized Ridge Regression for Sparse and High-Dimensional Linear Models

“…That is, C-reactive protein was significant by the generalized ridge estimator and was not by the ridge estimator. A study conducted in a large population in China reported that a high C-reactive protein level was an independent risk factor for severe intracerebral hemorrhage [38]. The selection of C-reactive protein as a variable associated with increased hematoma volume may reflect the tendency of patients with severe intracerebral hemorrhage to have easier hematoma expansion.…”

Elevated red blood cell distribution width levels predict depression after intracerebral hemorrhage: A 3-month follow-up study

“…Besides, the inflammatory response remarkably affects ICH. Upon the occurrence of ICH, the organism is capable of inducing a systemic inflammatory response while elevating the RDW, WBC, and CRP levels in ICH patients ( 40 , 56 , 57 ). Furthermore, previous reports demonstrated that high RDW reported increased inflammation indices, such as CRP and IL-6 ( 58 , 59 ).…”