C-Quaternary alkynyl glycinols via the Ritter reaction of cobalt complexed alkynyl glycols

Abstract

A novel approach to C-quaternary alkynyl glycinols based on the Ritter reaction of acetonitrile with cobalt complexed alkynyl glycols is presented.

10-Membered Azaenediyne Fused to a Benzothiophene through the Nicholas Macrocyclization: Synthesis and DNA Cleavage Ability

“…The latter are known to be synthesized by intramolecular Nicholas cyclization [10][11][12][13][14][15][16] and from two or more starting compounds by tandem cycloaddition process with the Nicholas-type reaction on a C-N bond-formation step. [17][18][19][20][21] Cycles of different sizes from 5-to 21-memebered rings have been prepared using these methodologies. Among 10-membered cyclic alkynes enediyne antibiotics with a (Z)-3-ene-1,5-diyne system in a 10-membered cycle are of special interest because of their ability to undergo the Bergman cycloaromatization under mild condi-tions with the formation of diradicals.…”