C-Phycocyanin protects against acute tributyltin chloride neurotoxicity by modulating glial cell activity along with its anti-oxidant and anti-inflammatory property: A comparative efficacy evaluation with N-acetyl cysteine in adult rat brain

Mitra, Sumonto; Siddiqui, Waseem Ahmad; Khandelwal, Shashi

doi:10.1016/j.cbi.2015.06.016

Cited by 46 publications

(25 citation statements)

References 77 publications

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“…The CCl 4triggered oxidative stress occurs through releasing free radicals; trichloromethyl (CCl 3 • ) and peroxy trichloromethyl (•OOCCl 3 ) capable of depleting the antioxidant capacity of the living cells. The direct antioxidant action of Anabaena oryzae phycocyanin may be due to its radical scavenging activity previously observed in vitro in line with the reported attenuating action of Spirulina phycocyanin on the neurotoxic potential of tributyltin chloride by reducing the oxidative stress and diminishing ROS levels efficiently(Mitra et al, 2015).…”

supporting

confidence: 79%

Alleviation of carbon tetrachloride‐induced hepatocellular damage and oxidative stress in rats by Anabaena oryzae phycocyanin

et al. 2020

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Phycocyanin isolated from Anabaena biomass was in-vitro assayed for its antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS [2,2′-azino-bis(3ethylbenzothiazoline-6-sulfonic acid)] free radical, revealing maximum activities amounting to 77 and 80% at 1,000 µg/ml and SC 50 values about 96 and 111 µg/ ml, respectively. A biological experiment was conducted, involving 40 male Wistar Albino rats, divided into five groups. Group I received only the basal diet as a normal control, while groups II, III, IV, and V were administrated intraperitoneal (IP) injection of a single dose of CCl 4 (50% in corn oil) at 0.5 ml/kg body weight. Subsequently, groups II, III, IV, and V received phycocyanin at 0.0, 25, 50, and 100 mg/kg body weight/day. CCl 4 induced considerable increases (p < .05) in the levels of serum ALT, AST, urea and creatinine, total lipid, and triglycerides coupled with significant reductions (p < .05) in serum antioxidant enzymes and some liver histopathological deformations compared to the negative control (group 1). Administration of Anabaena oryzae phycocyanin can counteract these CCl 4-induced changes. Practical applications Phycocyanin isolated from Anabaena has beneficial effects such as the antioxidant, antibacterial, anticancer, and hepatoprotective effect. Phycocyanin may play a key role in alleviating oxidative stress, artificially induced by carbon tetrachloride in Albino rats, to ultimately determine its capacity to serve as a natural antioxidant for food and health applications.

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supporting

confidence: 79%

Alleviation of carbon tetrachloride‐induced hepatocellular damage and oxidative stress in rats by Anabaena oryzae phycocyanin

et al. 2020

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“…Moreover, C-PC can improve the survival and proliferation ability, weaken the apoptosis of oxidized astrocytes and free radical scavenging ability, and cause no damage to the normal astrocytes and neurons. Mitra et al [ 114 ] compared the protective effects of C-PC and N-acetylcysteine (NAC, a neuroprotective drug) on tributyltin chloride-induced neurotoxicity. They found that both of them can reduce oxidative stress and inflammation, although their mechanisms vary; NAC can effectively regulate enzymes related to the oxidation pathway, whereas C-PC resists ROS.…”

Section: Antioxidationmentioning

confidence: 99%

Medical Application of Spirulina platensis Derived C‐Phycocyanin

Liu

Huang

Zhang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

136

128

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Along with the development of marine biological pharmaceutical research, high-effective and low-toxic drugs and functional foods isolated from marine organisms have become a new field of pharmacy and bromatology. The pharmacological actions, such as anti-inflammation, antioxidation, antitumor, immunological enhancement, and hepatorenal protection of C-phycocyanin (C-PC) from Spirulina platensis, have been reported, and C-PC has important value of development and utilization either as drug or as functional food. There are many researches about the various pharmacological actions and mechanisms of C-PC, but related reports are only to some extent integrated deeply and accurately enough, which put some limitations to the further application of C-PC in medicine. Particularly, with the improvement of living standards and attention to health issues, C-PC being a functional food is preferred by more and more people. C-PC is easy to get, safe, and nontoxic; thus, it has a great potential of research and development as a drug or functional food. Here, the separation and purification, physicochemical properties, physiological and pharmacological activities, safety, and some applications are reviewed to provide relevant basis for the development of natural medicine and applied products.

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“…Its antioxidant activity exhibits antipathologic effects in allergic rhinitis24 and obesity 25. Further, neuroprotective effects in the brain have been observed in animal models of Parkinson's disease26 and a neurotoxic model generated using tributyltin chloride 27. However, effects on the retina and vision have not been reported in animal experiments or clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Dietary Spirulina Supplementation Protects Visual Function From Photostress by Suppressing Retinal Neurodegeneration in Mice

Okamoto

Kawashima

Osada

et al. 2019

Trans. Vis. Sci. Tech.

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PurposeWe investigated whether daily consumption of Spirulina, an antioxidant generating cyanobacterial nutritional supplement, would suppress photostress-induced retinal damage and prevent vision loss in mice.MethodsSix-week-old male BALB/cAJcl mice were allowed constant access to either a standard or Spirulina-supplemented diet (20% Spirulina) that included the antioxidants, β-carotene and zeaxanthin, and proteins for 4 weeks. Following dark adaptation, mice were exposed to 3000-lux white light for 1 hour and returned to their cages. Visual function was analyzed by electroretinogram, and retinal histology by hematoxylin and eosin staining, terminal deoxynucleotidyl transferase-mediated, deoxyuridine triphosphate nick-end labeling (TUNEL) assay, and immunohistochemistry. Retinal expression of proteins, reactive oxygen species (ROS), and mRNAs were measured using immunoblot analysis, enzyme-linked immunosorbent assay (ELISA), 2′,7′-dichlorofluorescein-diacetate, or ROS Brite 700 Dyes, and real-time reverse-transcription polymerase chain reaction, respectively.ResultsLight-induced visual function impairment was suppressed by constant Spirulina intake. Thinning of the photoreceptor layer and outer segments, photoreceptor cell death, decreased rhodopsin protein, and induction of glial fibrillary acidic protein were ameliorated in the Spirulina-intake group. Increased retinal ROS levels after light exposure were reduced by Spirulina supplementation. Light-induced superoxide dismutase 2 and heme oxygenase-1 mRNAs in the retina, and Nrf2 activation in the photoreceptor cells, were preserved with Spirulina supplementation, despite reduced ROS levels, suggesting two pathways for suppressing ROS, scavenging and induction of endogenous antioxidative enzymes. Light-induced MCP-1 retinal mRNA and proteins were also suppressed by Spirulina.ConclusionsSpirulina ingestion protected retinal photoreceptors from photostress in the retina.Translational RelevanceSpirulina has potential as a nutrient supplement to prevent vision loss related to oxidative damage in the future.

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C-Phycocyanin protects against acute tributyltin chloride neurotoxicity by modulating glial cell activity along with its anti-oxidant and anti-inflammatory property: A comparative efficacy evaluation with N-acetyl cysteine in adult rat brain

Cited by 46 publications

References 77 publications

Alleviation of carbon tetrachloride‐induced hepatocellular damage and oxidative stress in rats by Anabaena oryzae phycocyanin

Alleviation of carbon tetrachloride‐induced hepatocellular damage and oxidative stress in rats by Anabaena oryzae phycocyanin

Medical Application of Spirulina platensis Derived C‐Phycocyanin

Dietary Spirulina Supplementation Protects Visual Function From Photostress by Suppressing Retinal Neurodegeneration in Mice

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