C-Phycocyanin isolated from Microcystis aeruginosa Kützing mitigates renal injury induced by potassium dichromate via toll-like receptor-4 down regulation in rats

Salama, Abeer; Hussein, Rehab A.; Mettwally, Walaa S. A.; Helmy, Mohamed S.; Ali, Gamila H.

doi:10.21608/ejchem.2021.63657.3362

Cited by 1 publication

(1 citation statement)

References 43 publications

(49 reference statements)

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“…Group 2 (EtOH), the EtOH-treated group, received distilled water orally (10 mL/kg), 1 hour before intraperitoneal EtOH injection with 10 mL/kg (38% v/v) [20]. Group 3, the phycocyanin-cotreated (PE) group, received phycocyanin extract (BioAlgues Tunisia) orally at a dose of 50 mg/kg [21,22], 1 hour before intraperitoneal EtOH injection. Lastly, group 4, the phycocyanin-treated (P) group, received only phycocyanin extract at a dose of 50 mg/kg.…”

Section: Experimental Designmentioning

confidence: 99%

Phycocyanin alleviates alcohol-induced testicular injury in male Wistar rats

Boukari,

Ghoghbane,

Khemissi

et al. 2024

Clin Exp Reprod Med

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Objective: Given the noteworthy implications of alcohol consumption and its association with male infertility, there has been a notable focus on investigating natural alternatives to mitigate its adverse effects. Thus, this study was conducted to assess the potential protective effect of phycocyanin extract derived from the blue algae Arthrospira (Spirulina) platensis against ethanol-induced oxidative stress, disturbances in testicular morphology, and alterations in sperm production.Methods: Male rats were divided into four groups (five rats each): the control group received a saline solution, the ethanol exposed group (EtOH) was subjected to intraperitoneal injections of 10 mL/kg of ethanol solution at a concentration of 38% (v/v), the phycocyanin alone treated group (P) received oral administration of phycocyanin at a dosage of 50 mg/kg, and the phycocyanin-cotreated group (PE) was given oral phycocyanin followed by ethanol injections. All treatments were administered over a period of 14 days.Results: Our findings demonstrated that ethanol exposure induced reproductive toxicity, characterized by reduced sperm production and viability, alterations in testicular weight and morphology, increased lipid peroxidation levels, and elevated oxidative enzyme activity. In addition, the ethanol-intoxicated group showed perturbations in serum biochemical parameters. However, the simultaneous exposure to ethanol and phycocyanin exhibited a counteractive effect against ethanol toxicity.Conclusion: The results showed that supplementation of phycocyanin prevented oxidative and testicular morphological damage-induced by ethanol and maintained normal sperm production, and viability.

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Section: Experimental Designmentioning

confidence: 99%