C-Phycocyanin attenuates cisplatin-induced nephrotoxicity in mice

On the occasion of world cancer day 2015; the possibility of cancer prevention or treatment with antioxidants: The ongoing cancer prevention researches

“…In an international trial reported in 2005, no effect of daily supplementation with 400 IU synthetic alpha-tocopherol which was administered for 7 years was seen in the incidence of major cardiovascular events such as stroke, heart attack or death from heart disease, cancer incidence or death from cancer in people diagnosed with cardiovascular disease or diabetes. [ 39 ]…”

“…The results showed that the use of these supplements for a period of about 5.5 years did not affect the incidence of prostate or other cancers. [ 39 40 ] Updated findings, reported in 2011, demonstrated that, following 1.5 years off supplements, the cases of prostate cancer among men taking Vitamin E alone were 17% more compared to placebo group. [ 41 ] No increase in prostate risk was observed for men assigned to take Vitamin E plus selenium or selenium alone compared with men assigned to take a placebo.…”

“…[ 41 ] No increase in prostate risk was observed for men assigned to take Vitamin E plus selenium or selenium alone compared with men assigned to take a placebo. [ 39 ]…”

Comment on: Pomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats

“…[ 21 ] These paradoxical actions of antioxidants have been demonstrated by other antioxidant compounds. [ 1 22 23 24 25 ] Therefore, the lack of protective effect of pomegranate in CP induced nephrotoxicity seems to be the pro-oxidant activity of pomegranate extract or low dose of this plant extract. [ 26 27 ]…”