C-peptide stimulates nitrites generation via the calcium-JAK2/STAT1 pathway in murine macrophage Raw264.7 cells

Lee, Soo Kyung; Lee, Jung Ok; Kim, Ji Hae; Jung, Jin Hee; You, Ga Young; Park, Sun Hwa; Kim, Hyeon Soo

doi:10.1016/j.lfs.2010.03.022

Cited by 18 publications

(14 citation statements)

References 29 publications

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“…Association study in Chinese Han population revealed that JAK2 played an important role in the susceptibility to AS [13]. The increase of cytosolic calcium resulted in the activation of JAK-STAT pathways, which, in turn, involved in the regulation of proinflammatory genes [32]. Our association studies in AS provided some indirect evidence that supported a role of calcium signaling in the susceptibility to AS.…”

Section: Discussionsupporting

confidence: 53%

Association of ORAI1 Haplotypes with the Risk of HLA-B27 Positive Ankylosing Spondylitis

et al. 2011

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Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The aetiology of ankylosing spondylitis is still unclear. Previous studies have indicated that genetics factors such as human leukocyte antigen HLA-B27 associates to AS susceptibility. We carried out a case-control study to determine whether the genetic polymorphisms of ORAI1 gene, a major component of store-operated calcium channels that involved the regulation of immune system, is a susceptibility factor to AS in a Taiwanese population. We enrolled 361 AS patients fulfilled the modified New York criteria and 379 controls from community. Five tagging single nucleotides polymorphisms (tSNPs) at ORAI1 were selected from the data of Han Chinese population in HapMap project. Clinical statuses of AS were assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Global Index (BAS-G). Our results indicated that subjects carrying the minor allele homozygote (CC) of the promoter SNP rs12313273 or TT homozygote of the SNP rs7135617 had an increased risk of HLA-B27 positive AS. The minor allele C of 3′UTR SNP rs712853 exerted a protective effect to HLA-B27 positive AS. Furthermore, the rs12313273/rs7135617 pairwise allele analysis found that C-G (OR 1.69, 95% CI 1.27, 2.25; p = 0.0003) and T-T (OR 1.75, 95% CI 1.36, 2.27; p<0.0001) haplotypes had a significantly association with the risk of HLA-B27-positive AS in comparison with the T-G carriers. This is the first study that indicate haplotypes of ORAI1 (rs12313273 and rs7135617) are associated with the risk of HLA-B27 positive AS.

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Section: Discussionsupporting

confidence: 53%

Association of ORAI1 Haplotypes with the Risk of HLA-B27 Positive Ankylosing Spondylitis

et al. 2011

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“…Phospholipase C activation evokes an increase in [Ca 2ϩ ] i , resulting in the concomitant NO generation (Forst et al, 1998b;Jensen and Messina, 1999;Wallerath et al, 2003;Joshua et al, 2005) and PKC. In the stimulation of NO generation, the calcium-Janus tyrosine kinase 2/signal transducer and activator of transcription 1 pathway is involved (Hills and Brunskill, 2009;Lee et al, 2010;Richard and Stephens, 2011). and PKC together with increased de novo synthesis of diacylglycerol (DAG) stimulates activation of Na ϩ /K ϩ -ATPase via PKC␣ translocation to the cell membrane.…”

Section: B C-peptide (Neuropathy Vascular Function)mentioning

confidence: 99%

Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes

Verspohl

2012

Pharmacol Rev

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“…Studies in macrophages also provide support for an immunomodulatory role for C-peptide. In this cell type, application of C-peptide increases nitrite production in association with induction of inducible nitric oxide synthase (iNOS), a prominent marker of macrophage activation [ 32 ] .…”

Section: C-peptide and The Endothelial Nitric Oxide Synthase (Enos)mentioning

confidence: 99%

“…Although the specifi c genes subject to regulation were not studied, gel mobility shift assays clearly demonstrated the binding of CREB to CRE in C-peptide treated cells [ 37 ] . In the studies of Lee et al [ 32 ] in macrophages, induction of nitrite production and iNOS expression by C-peptide was accompanied by phosphorylation and activation of Janus activated kinase (JAK)/signal transducer and activated transcription pathway (STAT) [ 32 ] . These data strongly support a role for C-peptide in regulating gene transcription.…”

Section: Effects Of C-peptide On Transcription Factorsmentioning

confidence: 99%

C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy

Brunskill

2011

Diabetes &Amp; C-Peptide

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C-peptide stimulates nitrites generation via the calcium-JAK2/STAT1 pathway in murine macrophage Raw264.7 cells

Cited by 18 publications

References 29 publications

Association of ORAI1 Haplotypes with the Risk of HLA-B27 Positive Ankylosing Spondylitis

Association of ORAI1 Haplotypes with the Risk of HLA-B27 Positive Ankylosing Spondylitis

Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes

C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy

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