C-peptide Predicts the Remission of Type 2 Diabetes After Bariatric Surgery

Abstract

Baseline C-peptide is commonly elevated in morbidly obese patients with T2DM. There was a marked reduction in C-peptide after a significant weight reduction 1 year after surgery with a T2DM remission rate of 78.0%. Thus, bariatric surgery is recommended for obesity-related T2DM patients with elevated C-peptide.

Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass

“…The present study revealed that C-peptide level was positively associated with diabetes remission after RYGB. This result is consistent with previous studies by Lee [19,29]. It is assumed that the elevated C-peptide levels in morbidly obese diabetic patients implicate well-preserved pancreatic β cell function capable enough to compensate for the increased insulin resistance.…”

Visceral fat area as a new predictor of short-term diabetes remission after Roux-en-Y gastric bypass surgery in Chinese patients with a body mass index less than 35 kg/m2

“…Many previous studies demonstrated that preoperative fasting C-peptide levels might be helpful for predicting T2DM outcome after RYGB [15][16][17]. In T2DM, C-peptide levels are above the normal range because of a compensatory increase in insulin production.…”

Predictors of Long-Term Diabetes Remission After Metabolic Surgery

“…Therefore, C-peptide levels in T2DM patients may reflect their pancreas preserve and predict the success of surgical treatment of T2DM. 47 Preoperative C-peptide was found to be an important predictor of diabetes remission after metabolic surgery in a recent study. 48 Although insulin level has the same meaning as C-peptide level and is also an important predictor of those who may benefit from bariatric surgery, 49 direct measurement of insulin level may be difficult in a T2DM patient receiving insulin therapy.…”