C-peptide and chronic complications in patients with type-2 diabetes and the metabolic syndrome

Relationship Between β-Cell Function, Metabolic Control, and Microvascular Complications in Type 2 Diabetes Mellitus

“…The relationship between C-peptide levels and metabolic control was reported in T2DM previously. Mavrakanas et al 23 found that C-peptide levels were higher in diabetes patients with metabolic syndrome regardless of the presence of diabetes complications. Consistent with this study, as the tertiles of serum AUC(C-pep) increased, increases in body mass index and TG levels and decreases in HDL-cholesterol were observed in our study as well.…”

Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia

“…Other studies found positive correlations between the comorbid metabolic syndrome and type 2 diabetes with all cardiovascular complications including DR[88,89]. Furthermore, other studies found that the presence of hyperinsulinemia and dyslipidemia in type 2 diabetics was associated with the onset of microvascular complications[90,91]. A case-controlled study, with data obtained from 2551 Chinese participants found that the trend to develop DR with metabolic syndrome was significantly higher than that without metabolic syndrome.…”

C‐peptide concentration, mortality and vascular complications in people with Type 2 diabetes. The Skaraborg Diabetes Register

“…Elevated concentrations are associated with insulin resistance and have been shown to be associated with cardiovascular and overall mortality in people without diabetes [6]. Prospective studies of the association between C-peptide concentrations and diabetic complications and death are limited and have contradictory results [7][8][9]. Furthermore, there are no studies on people with newly diagnosed diabetes.…”