C-mirna Expression Responses To Whole-body Vibration And Resistance Exercise In Postmenopausal Women

Buchanan, Samuel R.; Nguyen, Hoang Van; Miller, Ryan; Kellawan, J. Mikhail; Black, Christopher D.; Bemben, Michael G.; Bemben, Debra A.

doi:10.1249/01.mss.0000679460.59644.41

Cited by 1 publication

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“…There are gaps in the literature that need to be addressed, specifically more information is needed on bone-specific miRNA responses to resistance exercise, and more studies need to be conducted in women, especially postmenopausal women who are at greater risk for osteoporosis. Informed Consent Statement: Written informed consent was obtained from all subjects involved in the Buchanan study [36].…”

Section: Discussionmentioning

confidence: 99%

“…There is a paucity of data in the literature on c-miRNA responses to acute exercise in postmenopausal women. We recently studied the effects of acute resistance exercise and wholebody vibration on expression of selected c-miRNAs in physically active postmenopausal women aged 65-76 years [36]. This randomized crossover design study compared c-miRNA responses to a bout of resistance exercise (RE) (3 sets 10 reps 70% 1 repetition maximum (1RM), 5 exercises) and a bout of whole-body vibration (WBV) (5 sets 1 min bouts 20 Hz 3.38 mm peak to peak displacement.…”

Section: Circulating Mirnasmentioning

confidence: 99%

“…The data used to support the findings of the Buchanan study [36] are restricted by the University of Oklahoma IRB in order to protect participant privacy. Data may be available in aggregate form from the corresponding author upon request.…”

Section: Data Availability Statementmentioning

confidence: 99%

“…The study by Buchanan [36] was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the University of Oklahoma Health Sciences Center (IRB# 9569 approval date 14 August 2018).…”

Section: Institutional Review Board Statementmentioning

confidence: 99%

“…Informed Consent Statement: Written informed consent was obtained from all subjects involved in the Buchanan study [36].…”

Section: Institutional Review Board Statementmentioning

confidence: 99%

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Bone-Regulating MicroRNAs and Resistance Exercise: A Mini-Review

2022

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MicroRNAs (miRNA) are a class of short noncoding RNA that play important roles in controlling gene expression. Many miRNAs have been identified as being important regulators of bone cell function, thus affecting the bone remodeling processes. In addition to being expressed in specific tissues and exerting intracellular effects, miRNAs can enter the blood where they can be taken up by other tissues. These circulating miRNAs (c-miRNA) also have clinical significance as biomarkers of musculoskeletal diseases as they are tissue-specific, are stable and easily detectable, and require minimally invasive procedures. This mini-review discusses miRNAs with regulatory roles in bone metabolism and c-miRNA responses to acute bouts of resistance exercise. MiRNA responses (e.g., upregulation/downregulation of expression) vary depending on the resistance exercise protocol characteristics and the age of the participants. There are gaps in the literature that need to be addressed as most of the resistance exercise studies focused on miRNAs that regulate skeletal muscle in male participants.

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Section: Discussionmentioning

confidence: 99%

Section: Circulating Mirnasmentioning

confidence: 99%

Section: Data Availability Statementmentioning

confidence: 99%

Section: Institutional Review Board Statementmentioning

confidence: 99%

“…Informed Consent Statement: Written informed consent was obtained from all subjects involved in the Buchanan study [36].…”

Section: Institutional Review Board Statementmentioning

confidence: 99%