c-Maf Is Required for the Development of Dorsal Horn Laminae III/IV Neurons and Mechanoreceptive DRG Axon Projections

Hu, Jia; Huang, Tianwen; Li, Tingting; Guo, Zhen; Cheng, Leping

doi:10.1523/jneurosci.6239-11.2012

Cited by 40 publications

(34 citation statements)

References 66 publications

(91 reference statements)

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“…Further comparison of tdTomato and vesicular glutamate transporter vGluT2 expression confirmed that the RORα + INs are primarily glutamatergic, with 91.6±0.4% coexpressing vGluT2 (Figure 2C and E, Figure S2A–C). Moreover, a large fraction of them coexpressed cholecystokinin (Figure S2F), which is restricted to excitatory neurons in the dorsal horn (Hu et al, 2012; Xu et al, 2013). By contrast, only 3.1±0.9% of the RORα INs in Gad1-GFP mice expressed GFP (Figure 2D and E).…”

Section: Resultsmentioning

confidence: 99%

Identification of a Spinal Circuit for Light Touch and Fine Motor Control

Bourane

Grossmann

Britz

et al. 2015

Cell

170

217

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Sensory circuits in the dorsal spinal cord integrate and transmit multiple cutaneous sensory modalities including the sense of light touch. Here we identify a population of excitatory interneurons (INs) in the dorsal horn that are important for transmitting innocuous light touch sensation. These neurons express the ROR alpha (RORα) nuclear orphan receptor and are selectively innervated by cutaneous low threshold mechanoreceptors (LTMs). Targeted removal of RORα INs in the dorsal spinal cord leads a marked reduction in behavioral responsiveness to light touch without affecting responses to noxious and itch stimuli. RORα IN-deficient mice also display a selective deficit in corrective foot movements. This phenotype, together with our demonstration that the RORα INs are innervated by corticospinal and vestibulospinal projection neurons, argues that the RORα INs direct corrective reflex movements by integrating touch information with descending motor commands from the cortex and cerebellum.

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Section: Resultsmentioning

confidence: 99%

Identification of a Spinal Circuit for Light Touch and Fine Motor Control

Bourane

Grossmann

Britz

et al. 2015

Cell

170

217

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“…In an effort to address this question and to identify molecular markers of subsets of embryonic ventral INs, we analyzed the distribution of a set of transcription factors that have been described in the ventral part of the developing spinal cord relative to established markers of ventral IN populations. The transcription factor set included BhlhB5 (also known as Bhlhe22) [53], [68], [69], Prdm8 [54], [70], HNF-6, OC-2, OC-3 [55], Nurr1 [71], Pax2 [72], Pax6, MafA, MafB or cMaf [73], Pitx2 [38], Olig3 [74], Pou3F1 and Pou4F1 [75].…”

Section: Resultsmentioning

confidence: 99%

Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord

et al. 2013

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The spinal cord contains neuronal circuits termed Central Pattern Generators (CPGs) that coordinate rhythmic motor activities. CPG circuits consist of motor neurons and multiple interneuron cell types, many of which are derived from four distinct cardinal classes of ventral interneurons, called V0, V1, V2 and V3. While significant progress has been made on elucidating the molecular and genetic mechanisms that control ventral interneuron differentiation, little is known about their distribution along the antero-posterior axis of the spinal cord and their diversification. Here, we report that V0, V1 and V2 interneurons exhibit distinct organizational patterns at brachial, thoracic and lumbar levels of the developing spinal cord. In addition, we demonstrate that each cardinal class of ventral interneurons can be subdivided into several subsets according to the combinatorial expression of different sets of transcription factors, and that these subsets are differentially distributed along the rostrocaudal axis of the spinal cord. This comprehensive molecular profiling of ventral interneurons provides an important resource for investigating neuronal diversification in the developing spinal cord and for understanding the contribution of specific interneuron subsets on CPG circuits and motor control.

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“…Our studies consolidate the idea that distinct transcription factors control the formation of these nerve endings. The basic leucine-zipper transcription factor c-Maf and the ets domain protein Er81 are required for the formation of the Pacinian corpusles that are specialized to sense high-frequency vibrations (Sedý et al, 2006, Hu et al, 2012, Wende et al, 2012). Both c-Maf and the homeobox protein Shox2 are necessary for the formation of the Meissiner corpusles that respond to skin motions and detect low-frequency vibration (Abdo et al, 2011, Scott et al, 2011, Wende et al, 2012).…”

Section: Discussionmentioning

confidence: 99%