C. M. Wieland

Clark, Robert T.; Sengle, Friedrich

doi:10.2307/40095731

Cited by 6 publications

(6 citation statements)

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“…Thrust planes on a cirque glacier, for instance, would be expected to become at first steeper as one proceeded down-glacier, owing to continued passive flow, and then less steep as the effect of ablation predominated. This trend is broadly in accordance with what is observed (Clark 1951).…”

Section: Flow Of Glaciers and Ice-sheetssupporting

confidence: 92%

The flow of glaciers and ice-sheets as a problem in plasticity

Nye

1951

Proc. R. Soc. Lond. A

280

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A calculation is made of the distribution of stress and velocity in an ideal glacier and in an ideal ice-sheet. The ice is assumed to have a constant yield stress and to obey, like other polycrystalline plastic aggregates, the Levy-Mises equations of flow and either the Mises or the Tresca criterion of yielding. The solution obtained for an ideal glacier represents the two-dimensional flow of a long slab of ice down a gently undulating rough slope. The addition of ice to the upper surface by snowfall and the removal of ice by ablation are allowed for, but the frictional resistance of the sides of the glacier valley is neglected. Two states of flow are possible, ‘active’ and ‘passive’, corresponding to the active and passive Rankine states in soil mechanics. Which of these states occurs at a given place depends upon the relative magnitudes of the curvature of the bed and the rate of snowfall or ablation; a simple algebraic expression of this dependence is obtained. In both states of flow the velocity is greatest at the surface and decreases with depth according to an elliptical law. It is shown that, in accordance with observation, crevasses of limited depth can open in active flow but not in passive flow. The slip-line field for the problem has a close connexion with the directions and positions of shear faults (although the laminated structure of a glacier is doubtless also an important factor here). In passive flow the faults to be expected are similar to the ‘thrust planes’ often seen on glaciers. The theory suggests that in active flow a complementary sort of shear fault with the opposite direction of movement may occur—and there is some observational evidence for this. The tendency of glaciers to accentuate hollows in their beds is connected with the suggestion that erosion should proceed faster under passive flow than under active flow. The second solution obtained is formally similar but represents the two-dimensional flow of a large ice-sheet, such as the Greenland ice-cap. If a horizontal bed is assumed the profile is calculated to be formed from parts of two parabolas, the maximum height being given by the yield stress of ice. In the accumulation area flow is active. The maximum velocity is every where at the surface while the maximum shear rate is on the bed. The solution thus gives no support to the belief that the weight of ice above squeezes out the underlying ice at a faster rate.

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Section: Flow Of Glaciers and Ice-sheetssupporting

confidence: 92%

The flow of glaciers and ice-sheets as a problem in plasticity

Nye

1951

Proc. R. Soc. Lond. A

280

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“…The fact that population density has been observed to decrease with distance from the Central Business District and that the form of this relationship is rather consistent over different cities gives one a measure of the existing degree of sprawl. This consistency is shown in the papers by Clark [3] and Muth [13]. While differences between cities have been given a great deal of consideration, little attention has been focused on entire metropolitan areas.l This paper is aimed at providing a more precise measure of the distribution of population over space for metropolitan areas and, hopefully, will add to the understanding of some of the reasons for the spatial expansion of these areas.…”

Section: Introductionmentioning

confidence: 85%

“…41. 3 The components of the log-linear density gradient can be expressed as expected to spend more on housing than their lower income counterparts, the denominator of the right-hand side of Equation (3) will be larger for these families. This would lead to smaller price gradients in areas with a predominance of high income consumer^.^ This variance in price gradients, in turn, would be reflected in consumption patterns and density gradients.…”

Section: Theoretical Consideratioks and Three Hypothesesmentioning

confidence: 99%

Spatial Distribution of Population: Cities and Suburbs*

Martin¹

1973

Journal of Regional Science

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“…In this view,t he higher activity of 1 with respect to plakortins, can be explained by the fact that, while the H-shift reaction in 1 is favored by its constrained polycyclic structure, the higherc onformational flexibility of 2 and 3 limit the number of bioactive conformers. It has to be recurred that, in this case, the bioactivec onformers are those possessing the propers patial arrangement for the bioactivation reaction to occur.O nt he other hand, the large amount of hemei ron present in Pf infected erythrocytes with respect to normal host cells, [124] accounts for the observed selectivet oxicity of 2 and 3.…”

Section: Special Issuementioning

confidence: 99%

Use of Integrated Computational Approaches in the Search for New Therapeutic Agents

Persico

Dato

Orteca

et al. 2016

Molecular Informatics

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Computer-aided drug discovery plays a strategic role in the development of new potential therapeutic agents. Nevertheless, the modeling of biological systems still represents a challenge for computational chemists and at present a single computational method able to face such challenge is not available. This prompted us, as computational medicinal chemists, to develop in-house methodologies by mixing various bioinformatics and computational tools. Importantly, thanks to multi-disciplinary collaborations, our computational studies were integrated and validated by experimental data in an iterative process. In this review, we describe some recent applications of such integrated approaches and how they were successfully applied in i) the search of new allosteric inhibitors of protein-protein interactions and ii) the development of new redox-active antimalarials from natural leads.

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C. M. Wieland

Cited by 6 publications

References 0 publications

The flow of glaciers and ice-sheets as a problem in plasticity

The flow of glaciers and ice-sheets as a problem in plasticity

Spatial Distribution of Population: Cities and Suburbs*

Use of Integrated Computational Approaches in the Search for New Therapeutic Agents

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