C-geranylated flavonoids from Paulownia tomentosa Steud. fruit as potential anti-inflammatory agents

Molčanová, Lenka; Treml, Jakub; Leláková, Veronika; Maršík, Petr; Kurhan, Sebnem; Trávnı́ček, Zdeněk; Uhrín, Pavel; Šmejkal, Karel

doi:10.1016/j.jep.2022.115509

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…Steud. (Paulowniaceae) [121]. According to the author, among the compounds, Paulodiplacol A (78) (Figure 17) showed better anti-inflammatory activity by decreasing the action of NF-κβ after the addition of LPS.…”

Section: Flavonoidsmentioning

confidence: 99%

New Compounds from Terrestrial Plants: A Perspective View

Oliveira,

Kohatsu,

Hufnagel

et al. 2024

Compounds

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In an era where the search for innovative drug leads faces challenges, our study pivots towards exploring the untapped potential of plant-derived compounds, focusing on the period of 2021 to 2022. We assess the classes of compounds these new structures belong to; the plants and families these compounds belong to; and the degree of novelty of the compound compared with already-known structures. The review was conducted following the Preferred Reporting Items for Systematics Reviews and Meta-Analyses (PRISMA) statement checklist for the guided reporting of systematic reviews. A total of 464 articles were selected for the new compounds of natural origin survey. We included 117 complete articles in this review and reported approximately 109 new structures elucidated during the years 2021 and 2022. Many of the compounds showed small structural variations in relation to already-known molecules. For some, however, this small modification was decisive for the biological activity reported, demonstrating the importance of descriptive phytochemical studies.

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Section: Flavonoidsmentioning

confidence: 99%

New Compounds from Terrestrial Plants: A Perspective View

Oliveira,

Kohatsu,

Hufnagel

et al. 2024

Compounds

View full text Add to dashboard Cite

show abstract

“…Steud. (Paulowniaceae) [121]. According to the author, among the compounds Paulodiplacol A ( 58 A new flavonoid was obtained from the aerial parts of Polygonum tinctorium Aiton (Polygonaceae) and was identified as 3,5,3′,4′-Tetrahydroxy-6,7-methylendioxyflavone-3-O-β-ᴅglucopyranoside (60) [123].…”

Section: Flavonoidsmentioning

confidence: 99%

New Compounds from Plants: A Perspective View

Oliveira,

Kohatsu,

Hufnagel

et al. 2023

Preprint

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In view of the diminishing contribution of natural products from plants to the discovery of new chemical structures, the aim of this study was to compile the articles from 2021 to 2022, assessing: (1) which classes of compounds these new structures belong to; (2) which plants and families these compounds belong to and (3) assessing the degree of novelty of the compound with an already known structure. The review was elaborate following the Preferred Reporting Items for System-atics Reviews and Meta-analyses (PRISMA) statement checklist for guide reporting of systematic reviews. A total of 464 articles were selected for the new compounds of natural origin survey. We included 117 complete articles in this review and reported approximately 109 new structures elucidated during the years 2021 and 2022. Many of the compounds showed small structural var-iations in relation to already known molecules. For some, however, this small modification was decisive for the biological activity reported, demonstrating the importance of descriptive phytochemical studies.

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“…Then, various compounds mainly including iridoid glycosides, phenylpropanoids, flavonoids, sesquiterpenes and triterpenes were isolated and identified from Paulownia spp. by methods of modern spectroscopy and separation [15][16][17][18]. Many of these compounds displayed antibacterial, anti-inflammatory, anti-aging and anti-tumor biological activities [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Phytotoxic Effects and Potential Allelochemicals from Water Extracts of Paulownia tomentosa Flower Litter

Xiao,

Tan,

et al. 2024

Agronomy

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Flowers of Paulownia spp. wither and fall on a large scale after blooming in spring and have potential allelopathic effects on surrounding plants, including crops and weeds. In this study, the phytotoxic effects of water extracts of Paulownia tomentosa flower litter (EPF) on wheat (Triticum aestivum L.), lettuce (Lactuca sativa L.), green bristlegrass (Setaria viridis L.) and purslane (Portulaca oleracea L.) were evaluated in the laboratory. The mode of action of the phytotoxicity of EPF on lettuce seedlings was studied and the secondary metabolites in EPF were analyzed by liquid chromatography high-resolution mass spectrometry (LC-HRMS). The results show that EPF significantly inhibited the seed germination and seedling growth of four target plants in a concentration-dependent manner. In addition, EPF could induce the excessive accumulation of reactive oxygen species (ROS) flowing with oxidative damage of the lipid bilayer of the biofilm, resulting in reduced cell viability and even apoptosis in lettuce. There were 66 secondary metabolites identified by LC-HRMS in P. tomentosa flowers. Among them, 10 compounds, including salicylic acid, caffeic acid, parthenolide, 7-hydroxycoumarin and abscisic acid (ABA), were all known allelochemicals. In summary, P. tomentosa flower litter displayed significant allelopathic effects, which were related to the accumulation of ROS in target plants. Phenolic acids, flavonoids as well as ABA are probably the main allelochemicals of P. tomentosa flowers.

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C-geranylated flavonoids from Paulownia tomentosa Steud. fruit as potential anti-inflammatory agents

Cited by 5 publications

References 40 publications

New Compounds from Terrestrial Plants: A Perspective View

New Compounds from Terrestrial Plants: A Perspective View

New Compounds from Plants: A Perspective View

Phytotoxic Effects and Potential Allelochemicals from Water Extracts of Paulownia tomentosa Flower Litter

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