c-Fos expression in the ascending arousal system induced by physical exercise in rats: Implication for memory performance

Grinspun, Noemí; Fuentealba, Yerko; Falcon, Romina; Valdés, José Luís

doi:10.1016/j.brainres.2019.146376

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…The time spent exploring a novel object was considered as a memory index (time spent exploring the new object divided by the total time spent exploring the old and new objects). Values of memory index lower than 0.5 indicate a recognition memory deficit [ 62 ]. AS rats showed a decreased memory index (by 50%, p < 0.005), compared to that shown by CS rats ( Figure 8 F).…”

Section: Resultsmentioning

confidence: 99%

“…Exploratory behavior was monitored at P30 with a video camera, with the animals placed in a square arena (open field) in a noise-free room as previously described [ 38 , 62 ]. When monitoring rats at P7, the rat was placed in the center of a square arena (21 × 29 cm, with a continuous wall 15 cm high) to freely explore for 5 min, monitoring the total traveled distance (cm) (locomotor activity).…”

Section: Methodsmentioning

confidence: 99%

“…The novel object recognition test was used to evaluate recognition memory, assessed at P30 as previously described [ 38 , 62 ]. Briefly, the animals were first habituated to a box and then exposed to two identical plastic objects for 5 min, letting the animals freely explore and get familiar with the objects.…”

Section: Methodsmentioning

confidence: 99%

“…Offline analysis of the video recording evaluated the time expended exploring the new object, versus the total time exploring the old and the new object, as an index of memory recognition [ 106 ]. A memory index below 0.5 indicated memory recognition deficit [ 62 , 106 ]. This index was recorded with an automated video-tracking Matlab routine (Mathworks, Inc, USA).…”

Section: Methodsmentioning

confidence: 99%

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Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia

Farfan

Carril

Redel

et al. 2020

IJMS

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Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global PA, we investigated the neuroprotective effect of intranasally administered secretome, derived from human adipose mesenchymal stem cells (MSC-S), preconditioned with either deferoxamine (an hypoxia-mimetic) or TNF-α+IFN-γ (pro-inflammatory cytokines). PA was generated by immersing fetus-containing uterine horns in a water bath at 37 °C for 21 min. Thereafter, 16 μL of MSC-S (containing 6 μg of protein derived from 2 × 105 preconditioned-MSC), or vehicle, were intranasally administered 2 h after birth to asphyxia-exposed and control rats, evaluated at postnatal day (P) 7. Alternatively, pups received a dose of either preconditioned MSC-S or vehicle, both at 2 h and P7, and were evaluated at P14, P30, and P60. The preconditioned MSC-S treatment (i) reversed asphyxia-induced oxidative stress in the hippocampus (oxidized/reduced glutathione); (ii) increased antioxidative Nuclear Erythroid 2-Related Factor 2 (NRF2) translocation; (iii) increased NQO1 antioxidant protein; (iv) reduced neuroinflammation (decreasing nuclearNF-κB/p65 levels and microglial reactivity); (v) decreased cleaved-caspase-3 cell-death; (vi) improved righting reflex, negative geotaxis, cliff aversion, locomotor activity, anxiety, motor coordination, and recognition memory. Overall, the study demonstrates that intranasal administration of preconditioned MSC-S is a novel therapeutic strategy that prevents the long-term effects of perinatal asphyxia.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia

Farfan

Carril

Redel

et al. 2020

IJMS

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“…Grinspun et al research in 2019 47 explained that running wheel exercise improves memory, as evaluated by increased c-Fos immunoreactivity in the tuberomammillary nucleus (TMN). Similarly, treadmill exercise is shown to benefit several neurodegenerative diseases, such as Alzheimer's, by increasing c-Fos expression in the hippocampus in mice after streptozotocin (STZ) injection, reducing long-term memory deficits 48 .…”

Section: Resultsmentioning

confidence: 99%

Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review

Rahmi,

Goenawan,

Sylviana

et al. 2024

Dement. neuropsychol.

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ABSTRACT. The immediate early gene exhibits activation markers in the nervous system consisting of ARC, EGR-1, and c-Fos and is related to synaptic plasticity, especially in the hippocampus. Immediate early gene expression is affected by physical exercise, which induces direct ARC, EGR-1, and c-Fos expression. Objective: To assess the impact of exercise, we conducted a literature study to determine the expression levels of immediate early genes (ARC, c-Fos, and EGR-1). Methods: The databases accessed for online literature included PubMed-Medline, Scopus, and ScienceDirect. The original English articles were selected using the following keywords in the title: (Exercise OR physical activity) AND (c-Fos) AND (Hippocampus), (Exercise OR physical activity) AND (ARC) AND (Hippocampus), (Exercise OR physical activity) AND (EGR-1 OR zif268) AND (Hippocampus). Results: Physical exercise can affect the expression of EGR-1, c-Fos, and ARC in the hippocampus, an important part of the brain involved in learning and memory. High-intensity physical exercise can increase c-Fos expression, indicating neural activation. Furthermore, the expression of the ARC gene also increases due to physical exercise. ARC is a gene that plays a role in synaptic plasticity and regulation of learning and memory, changes in synaptic structure and increased synaptic connections, while EGR-1 also plays a role in synaptic plasticity, a genetic change that affects learning and memory. Overall, exercise or regular physical exercise can increase the expression of ARC, c-Fos, and EGR-1 in the hippocampus. This reflects the changes in neuroplasticity and synaptic plasticity that occur in response to physical activity. These changes can improve cognitive function, learning, and memory. Conclusion: c-Fos, EGR-1, and ARC expression increases in hippocampal neurons after exercise, enhancing synaptic plasticity and neurogenesis associated with learning and memory.

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Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice

Huang,

Liu,

Chen

et al. 2024

Mol Neurobiol

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c-Fos expression in the ascending arousal system induced by physical exercise in rats: Implication for memory performance

Cited by 6 publications

References 31 publications

Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia

Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia

Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review

Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice

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