C for colored urine: Acute hemolysis induced by high-dose ascorbic acid

Huang, Yung-Chieh; Chang, Te‐Kau; Fu, Yun‐Ching; Jan, Sheng-Ling

doi:10.3109/15563650.2014.954124

Cited by 16 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been four published case reports of acute haemolysis induced by high dose vitamin C in patients with G6PD deficiency. [4][5][6][7] The pathophysiology is uncertain, but it likely involves the production of reactive oxygen species, which rapidly exhaust red blood cells glutathione supply. In one case, haemolysis, acute renal failure and death resulted after the administration of 80 g intravenous vitamin C. 6 Our patient survived, but required prolonged hospitalisation and intensive haematological and dialysis support, resulting in substantial costs to the health care system and significant distress to the patient and his family.…”

mentioning

confidence: 99%

Massive oxidative haemolysis and renal failure caused by high dose vitamin C

Rees

Strach

Burbury

et al. 2018

Medical Journal of Australia

View full text Add to dashboard Cite

mentioning

confidence: 99%

Massive oxidative haemolysis and renal failure caused by high dose vitamin C

Rees

Strach

Burbury

et al. 2018

Medical Journal of Australia

View full text Add to dashboard Cite

“…It has been demonstrated that pharmalogical doses of Vitamin C would relieve hemolysis within patients that suffered from G6PD deficiency [12][13][14]. Nonetheless, it was undeniable that over-dose Vitamin C could also contribute to aggravated haemolysis of G6PD-deficient erythrocytes, as reported in both case reports and mechanism researches [15][16][17]. Thus, this study was intended to investigate the eryptosis conditions among the population with G6PD deficiency or nomal activity habituated in Daidehong prefecture of Yunnan province and to explore the inherent mechanisms with in-vitro erythrocytes that were treated with proper concentrations of Vitamin C and hydrogen peroxide.…”

Section: Introductionmentioning

confidence: 75%

Vitamin C Inhibits Aggravated Eryptosis by Hydrogen Peroxide in Glucose-6-Phosphated Dehydrogenase Deficiency

Shan

Yang

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: The study was aimed to investigate if vitamin C could exert protective effects on development of eryptosis caused by glucose-6-phosphate dehydrogenase (G6PD) deficiency and hydrogen peroxide. Methods: Isolated erythrocytes with different G6PD activity (normal or deficient) were divided into various groups treated by either Vitamin C or H₂O₂. Phosphatidylserine (PS) extroversion rate was detected by Annexin V binding. The intracellular Ca²⁺ concentration was detected by Fluo3-fluorescence, and western blot was used to detect the expression of apoptosis factor caspase 3. Results: Compared with the blank group, the PS extroversion rate (P < 0.001), intracellular Ca²⁺ concentration (P < 0.001) and active caspase 3 expression level (P < 0.05) of erythrocytes significantly increased after treatment of 0.05% H₂O₂. Then the index of eryptosis significantly decreased after erythrocytes were treated with Vitamin C (1 mg/ml) for 30 min (all P < 0.05). The decline in erythrocytes with G6PD normal activity was more significant than those with G6PD deficiency. Conclusion: Vitamin C could effectively inhibit the eryptosis contributed by H₂O₂ oxidative stress, and the suppression on eryptosis with G6PD normal activity was more effective than that with G6PD deficiency.

show abstract

“…Four case reports described episodes of haemolysis in G6PD‐deficient individuals following use of high doses of 3 and 40 g ascorbic acid daily . One case report described the death of a 68‐year‐old black male who was given 80 g of ascorbic acid intravenously for burns .…”

Section: Resultsmentioning

confidence: 99%

Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review

Lee

Lai

Chaiyakunapruk

et al. 2016

Brit J Clinical Pharma

View full text Add to dashboard Cite

Aim Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals. Methods We searched 14 electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals. Additional publications were identified from manually searching textbooks, conference abstracts and the grey literature. All study designs were included as long as they contained clinical information. These gathered findings were summarized narratively. Results Thirty‐two publications met inclusion criteria. These reported on 10 herbal and dietary supplements. Overall evidence linking haemolysis to a herbal/dietary supplement was only found for henna. No evidence of harm was observed for vitamin C, vitamin E, vitamin K, Gingko biloba and α‐lipoic acid. Conclusions The review showed that there was insufficient evidence to contravene the use of most herbal or dietary products at therapeutic doses in G6PD deficient subjects.

show abstract

C for colored urine: Acute hemolysis induced by high-dose ascorbic acid

Cited by 16 publications

References 5 publications

Massive oxidative haemolysis and renal failure caused by high dose vitamin C

Massive oxidative haemolysis and renal failure caused by high dose vitamin C

Vitamin C Inhibits Aggravated Eryptosis by Hydrogen Peroxide in Glucose-6-Phosphated Dehydrogenase Deficiency

Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review

Contact Info

Product

Resources

About