C fibre innervation of a mechanoreceptor

Loewenstein, Werner R.; Goto, Kashima; Noback, Charles R.

doi:10.1007/bf02175859

Cited by 20 publications

(2 citation statements)

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“…Recently, we have also observed multiinnervated and multicored Pacinian corpuscles in the human pancreas (García-Suarez et al, unpublished). Additional innervation by unmyelinated axons has been found in Pacinian corpuscles from the cat mesentery (Kumamoto et al, 1993;Loewenstein et al, 1962;Santini et al, 1971). Some authors claim that these axons are sensitive (Malinovsky and Pac, 1982), but others say that they are sympathetic (Akoev et al, 1988;Chelyshev et al, 1982).…”

Section: Meissner and Pacinian Corpusclesmentioning

confidence: 92%

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

Vega

García‐Suárez

Montano

et al. 2008

Microscopy Res & Technique

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This article reviews the biochemical, physiological, and experimental data cumulated during the last decade on the Meissner and Pacinian corpuscles. It includes information about (i) the localization of molecules recently detected in sensory corpuscles; (ii) the unsolved problem of the accessory fibers in sensory corpuscles and the occurrence of myelin within them; (iii) the development of sensory corpuscles, especially their neuronal and growth factor dependency; (iv) the composition and functional significance of the extracellular matrix as an essential part of the mechanisms involved in the genesis of the stimuli generated in sensory corpuscles; (v) the molecular basis of mechanotransduction; (vi) a miscellaneous section containing sparse new data on the protein composition of sensory corpuscles, as well as in the proteins involved in live-death cell decisions; (vii) the changes in sensory corpuscles as a consequence of aging, the central, or peripheral nervous system injury; and finally, (viii) the special interest of Meissner corpuscles and Pacinian corpuscles for pathologists for the diagnosis of some peripheral neuropathies and neurodegenerative diseases.

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Section: Meissner and Pacinian Corpusclesmentioning

confidence: 92%

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

Vega

García‐Suárez

Montano

et al. 2008

Microscopy Res & Technique

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show abstract

“…Indeed, the studies in which the unmyelinated terminal of the afferent axon of the pacinian corpuscle was found to be the locus of energy transduction (Loewenstein and Rathkamp, 1958) preceded the earliest observation that the corpuscles are additionally innervated (Loewenstein et al, 1962) and, thus, never eliminated the possibility that the adrenergic fibers might themselves be the primary mechanosensitive structures with generator potential production in the afferent axon, a secondary process. The present investigation is concerned with the effect of the noradrenergic innervation in modulating or enabling transducer responsiveness and, further, addresses the question of whether the noradrenergic fibers are themselves the site of the initial energy transduction.…”

Section: Introductionmentioning

confidence: 99%

Role of the Sympathetic Innervation of the Pacinian Corpuscle

Schiff

1974

The Journal of General Physiology

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An investigation was made into the nature of the role played by the noradrenergic innervation of the pacinian corpuscle. Corpuscles of the cat mesentery and mesocolon were used in all experiments. Blockade of noradrenergic beta receptors by dichloroisoproterenol and interference with norepinephrine release by reserpine are each capable of reversibly blocking mechanoelectric transduction by the pacinian corpuscle. The monoamine oxidase inhibitors iproniazid and phenelzine are capable of protecting the transducer from the blocking effects of reserpine. It is concluded that the presence of norepinephrine, as maintained by sympathetic tonus, is required for the afferent nerve terminal of the pacinian corpuscle to be mechanosensitive.

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The Morphology of Muscle Receptors

Barker¹

1974

Handbook of Sensory Physiology

172

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C fibre innervation of a mechanoreceptor

Cited by 20 publications

References 1 publication

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

The Meissner and Pacinian sensory corpuscles revisited new data from the last decade

Role of the Sympathetic Innervation of the Pacinian Corpuscle

The Morphology of Muscle Receptors

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