c-erbB-2 oncoprotein expression in primary and advanced breast cancer

Prognostic Association of C-Erbb-2 Oncogene Amplification and Protein Overexpression in Human Breast Cancer Using Archival Tissues a Comparative Study

“…Ovet-expression of c-erbB-2 protein, on the other hand, was strongly correlated with DFS and S in our patients. Although some earlier studies have failed to show an association between prognosis and overexpression of the c-erbB-2 protein detected by IHC (14,15,20), there is a gencral agreement among more recently published reports that overexpression of the c-erbB-2 gene product is related to poor survival in breast cancer (10)(11)(12)(13)(33)(34)(35)(36). Our results are consistent with this emerging consensus.…”

C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators

“…The majority of tumours in both series exhibited moderate immunoreactivity but a substantial proportion in both the primary and advanced series exhibited strong positivity (Figure 2 (Sainsbury et al, 1985(Sainsbury et al, , 1987Nicholson et al, 1990 (Slamon et al, 1987). Further studies have supported this association (Wright et al, 1989;Gullick et al, 1991;Lovekin et al, 1991). An inverse association has also been demonstrated between c-erbB-2 expression and ER status (Slamon et al, 1987).…”

Expression of c-erbB-2 protein in papillary thyroid carcinomas

“…Two cases demonstrated almost exclusively cytoplasmic staining, of stronger degree, and two cases exhibited membrane staining only. The membrane staining has been regarded as specific for c-erbB-2 protein expression in breast carcinomas, and this staining pattern is associated with gene amplification and of prognostic significance in these tumours Lovekin et al, 1991).…”

“…c-erbB-2 protein overexpression is currently being evaluated as a potential risk factor in breast cancer patients Lovekin et al, 1991;O'Reilly et al, 1991;Winstanley et al, 1991).…”