C.el Phosphatome: A Catalogue of Actual and Pseudo Phosphatases Based on In-Silico Studies in Caenorhabditis elegans

Fatima, Sana; Shukla, Shikha; Nazir, Aamir

doi:10.1007/s10930-018-9794-6

Cited by 1 publication

(2 citation statements)

References 33 publications

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“…Phylogenetic tree of all active cysteine‐based class I (CC1) phosphatases in C. elegans . Tree is based on a multiple sequence alignment of all catalytically active CC1 phosphatases [ 11 ] performed using the clustal omega program [ 62 ]. Families/subfamilies shown in color: Protein tyrosine phosphatases (PTP), receptor type PTPs (PTPR), dual specificity phosphatases (DSP), phosphatase and tensin homologs (PTEN) and myotubularins.…”

Section: Resultsmentioning

confidence: 99%

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The protein tyrosine phosphatase PPH‐7 is required for fertility and embryonic development in C. elegans at elevated temperatures

Franziscus,

Ritz,

Kappel

et al. 2024

FEBS Open Bio

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Post‐translational modifications are key in the regulation of activity, structure, localization, and stability of most proteins in eukaryotes. Phosphorylation is potentially the most studied post‐translational modification, also due to its reversibility and thereby the regulatory role this modification often plays. While most research attention was focused on kinases in the past, phosphatases remain understudied, most probably because the addition and presence of the modification is more easily studied than its removal and absence. Here, we report the identification of an uncharacterized protein tyrosine phosphatase PPH‐7 in C. elegans, a member of the evolutionary conserved PTPN family of phosphatases. Lack of PPH‐7 function led to reduction of fertility and embryonic lethality at elevated temperatures. Proteomics revealed changes in the regulation of targets of the von Hippel–Lindau (VHL) E3 ligase, suggesting a potential role for PPH‐7 in the regulation of VHL.

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Section: Resultsmentioning

confidence: 99%

“…Humans express 81 active PTPs and 85 active PTKs [ 10 ]. This complexity is only mildly reduced in the nematode C. elegans , which expresses 57 PTPs, most of which remain unstudied [ 11 ]. These 57 active PTPs are outnumbered by 92 active PTKs [ 12 ], indicating that the phosphatases exhibit a broader substrate specificity than their kinase counterparts.…”

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confidence: 99%