C/EBPβ: The structure, regulation, and its roles in inflammation-related diseases

Ren, Qun; Liu, Zhaowen; Wu, Longhuo; Yin, Guoqiang; Xie, Xunlu; Kong, Weihao; Zhou, Jianguo; Liu, Shiwei

doi:10.1016/j.biopha.2023.115938

Cited by 3 publications

(2 citation statements)

References 160 publications

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“…Transcripts more highly detected in the aortic root of LDS mice relative to the ascending aorta included Agtr1a, which codes for angiotensin II receptor type 1a, a known contributor to LDS pathogenesis, and Gata4, which codes for a transcription factor known to positively regulate Agtr1a expression in the heart 44,45 . CCAAT enhancer binding protein beta (Cebpb), a pro-inflammatory mediator 46 , and maternally expressed gene 3 (Meg3), a long non-coding RNA (lncRNA) that negatively regulates TGF-β signaling and promotes VSMC proliferation [47][48][49][50] , were also enriched in this region. In contrast, expression of cardiac mesoderm enhancer-associated noncoding RNA (Carmn), a positive regulator of VSMC contractile function that is downregulated in vascular disease, and expression of Myh11, a marker of differentiated VSMCs, was enriched in the distal ascending aorta, a region that is only mildly affected in LDS mouse models 49,[51][52][53] .…”

Section: Resultsmentioning

confidence: 99%

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Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

Bramel,

Camejo,

Creamer

et al. 2024

Preprint

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Loeys-Dietz syndrome (LDS) is an aneurysm disorder caused by mutations that decrease transforming growth factor-β (TGF-β) signaling. Although aneurysms develop throughout the arterial tree, the aortic root is a site of heightened risk. To identify molecular determinants of this vulnerability, we investigated the heterogeneity of vascular smooth muscle cells (VSMCs) in the aorta of Tgfbr1M318R/+ LDS mice by single cell and spatial transcriptomics. Reduced expression of components of the extracellular matrix-receptor apparatus and upregulation of stress and inflammatory pathways were observed in all LDS VSMCs. However, regardless of genotype, a subset of Gata4-expressing VSMCs predominantly located in the aortic root intrinsically displayed a less differentiated, proinflammatory profile. A similar population was also identified among aortic VSMCs in a human scRNAseq dataset. Postnatal VSMC-specific Gata4 deletion reduced aortic root dilation in LDS mice, suggesting that this factor sensitizes the aortic root to the effects of impaired TGF-β signaling.

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Section: Resultsmentioning

confidence: 99%

“…8 and Supplemental Fig. 8), which code for proinflammatory transcription factors regulated by and/or interacting with Gata4 in other contexts 43 , 46 , 85 , 86 , which were highly expressed in VSMC2 relative to VSMC1, and further upregulated in the presence of LDS mutations ( Fig. 1 , Fig.…”

Section: Resultsmentioning

confidence: 99%

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

Bramel,

Camejo,

Creamer

et al. 2024

Preprint

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Hordenine Alleviates Lipopolysaccharide-Induced Mastitis by Suppressing Inflammation and Oxidative Stress, Modulating Intestinal Microbiota, and Preserving the Blood–Milk Barrier

Xie,

Li,

et al. 2024

J. Agric. Food Chem.

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Mastitis is a common mammalian disease occurring in the mammary tissue and poses a major threat to agriculture and the dairy industry. Hordenine (HOR), a phenylethylamine alkaloid naturally extracted from malt, has various pharmacological effects, but its role in mastitis is unknown. The aim of this study was to investigate the role of HOR and its underlying mechanism in a lipopolysaccharide (LPS)-induced inflammatory response model of mouse mammary epithelial cells (EpH4-Ev) and mouse mastitis model. The experimental results showed that HOR attenuated LPS-induced mammary tissue damage (from 3.75 ± 0.25 to 1.75 ± 0.25) and restored the integrity of the blood−milk barrier. Further mechanistic studies revealed that HOR inhibited LPSinduced overactivation of the TLR4-MAPK/NF-κB signaling pathway and activated the AMPK/Nrf2/HO-1 signaling pathway. Additionally, HOR altered the composition of the intestinal microbiota in mice, ultimately reducing the extent of inflammatory injury (from 3.33 ± 0.33 to 0.67 ± 0.33) and upregulating the expression of tight junction proteins (ZO-1, occludin, and claudin-3). The findings of this study provide a theoretical basis in the rational use of HOR for the prevention and treatment of mastitis and the maintenance of mammalian mammary gland health.

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The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin

Kiełbowski,

Bakinowska,

Bratborska

et al. 2024

Expert Opinion on Therapeutic Targets

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C/EBPβ: The structure, regulation, and its roles in inflammation-related diseases

Cited by 3 publications

References 160 publications

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model

Hordenine Alleviates Lipopolysaccharide-Induced Mastitis by Suppressing Inflammation and Oxidative Stress, Modulating Intestinal Microbiota, and Preserving the Blood–Milk Barrier

The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin

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