c‐di‐GMP Signaling

Pesavento, Christina; Hengge, Regine

doi:10.1002/9783527629237.ch21

Cited by 4 publications

(12 citation statements)

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“…To achieve this analytical result, we make a number of assumptions, the most important being that the environmental feedback depends on the instantaneous growth rate rather than on the population size. Although this is a rather idealized assumption, microbe-host interactions are in reality likely to be sensitive to microbial growth rate [25], since several intracellular small molecules and proteins, including ppGpp, cAMP and H-NS, whose concentrations are growth-rate dependent [26,27], have been shown to regulate microbial virulence factors [28][29][30].…”

Section: Discussion and Further Directionsmentioning

confidence: 99%

Switching and Growth for Microbial Populations in Catastrophic Responsive Environments

Visco

Allen

Majumdar

et al. 2010

Biophysical Journal

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Phase variation, or stochastic switching between alternative states of gene expression, is common among microbes, and may be important in coping with changing environments. We use a theoretical model to assess whether such switching is a good strategy for growth in environments with occasional catastrophic events. We find that switching can be advantageous, but only when the environment is responsive to the microbial population. In our model, microbes switch randomly between two phenotypic states, with different growth rates. The environment undergoes sudden catastrophes, the probability of which depends on the composition of the population. We derive a simple analytical result for the population growth rate. For a responsive environment, two alternative strategies emerge. In the no-switching strategy, the population maximizes its instantaneous growth rate, regardless of catastrophes. In the switching strategy, the microbial switching rate is tuned to minimize the environmental response. Which of these strategies is most favorable depends on the parameters of the model. Previous studies have shown that microbial switching can be favorable when the environment changes in an unresponsive fashion between several states. Here, we demonstrate an alternative role for phase variation in allowing microbes to maximize their growth in catastrophic responsive environments.

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Section: Discussion and Further Directionsmentioning

confidence: 99%

Switching and Growth for Microbial Populations in Catastrophic Responsive Environments

Visco

Allen

Majumdar

et al. 2010

Biophysical Journal

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“…1 These regulatory networks are complex and rely on the coordination of many different interacting components to induce the appropriate biological response. One vital component of many signaling pathways are intracellular small molecules known as second messengers 2,3 (Fig. 1).…”

Section: Second Messenger Signaling In Bacteriamentioning

confidence: 99%

“…These changing second messenger levels are sensed by specific effector molecules, which, in response to second messenger binding, act to induce the appropriate physiological output. 2,3 The behavioral responses induced by second messengers are often critical for survival, underscoring the crucial role of these small molecules in signal transduction.…”

Section: Second Messenger Signaling In Bacteriamentioning

confidence: 99%

The bacterial second messenger c-di-GMP: probing interactions with protein and RNA binding partners using cyclic dinucleotide analogs

Shanahan

Strobel

2012

Org. Biomol. Chem.

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The ability of bacteria to adapt to a changing environment is essential for their survival. One mechanism used to facilitate behavioral adaptations is the second messenger signaling molecule bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP). c-di-GMP is widespread throughout the bacterial domain and plays a vital role in regulating the transition between the motile planktonic lifestyle and the sessile biofilm forming state. This second messenger also controls the virulence response of pathogenic organisms and is thought to be connected to quorum sensing, the process by which bacteria communicate with each other. The intracellular concentration of c-di-GMP is tightly regulated by the opposing enzymatic activities of diguanlyate cyclases and phosphodiesterases, which synthesize and degrade the second messenger, respectively. The change in the intracellular concentration of c-di-GMP is directly sensed by downstream targets of the second messenger, both protein and RNA, which induce the appropriate phenotypic response. This review will summarize our current state of knowledge of c-di-GMP signaling in bacteria with a focus on protein and RNA binding partners of the second messenger. Efforts towards the synthesis of c-di-GMP and its analogs are discussed as well as studies aimed at targeting these macromolecular effectors with chemically synthesized cyclic dinucleotide analogs.

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“…In plants, these enzymes have been implicated in oxidative signaling , including the maintenance of cellular redox homeostasis (Ge et al, 2007) and resistance to exogenous reactive oxygen species (Tong et al, 2009). In bacteria, nucleotide-based second messengers are involved in a range of signaling functions (Pesavento & Hengge, 2009), including the oxidative stress response (Johnstone & Farr, 1991). Similarly, the DUF1285 family might carry out a signaling function related to oxidative stress, possibly through binding to a small nucleotide derivative.…”

Section: Gene-fusion and Genome-context Analysismentioning

confidence: 99%

Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction

et al. 2010

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c‐di‐GMP Signaling

Cited by 4 publications

References 100 publications

Switching and Growth for Microbial Populations in Catastrophic Responsive Environments

Switching and Growth for Microbial Populations in Catastrophic Responsive Environments

The bacterial second messenger c-di-GMP: probing interactions with protein and RNA binding partners using cyclic dinucleotide analogs

Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction

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