C-centered radical-initiated cyclization by directed C(sp³)–H oxidative functionalization

Abstract

C(sp3)−H functionalization has been proved to be challenging to develop and therefore is attracting constant attention. It provides an opportunity to obviate the requirement for a preexisting functional handle and...

Catalytic alkane C–H functionalization by carbene insertion into unactivated C(sp3)–H bonds

“…3 As such, the selective C-H functionalization of alkanes is in high demand yet remains a formidable challenge for modern organic synthesis. The established strategies for selective C-H functionalization of alkanes are limited and fall into three categories: (i) metalcatalyzed C-H activation by actually inserting itself between carbon and hydrogen, [4][5][6] (ii) outer-sphere processes involving hydrogen atom transfer 7,8 or radical processes, [9][10][11][12][13] and (iii) metallocarbene C(sp 3 )-H insertion reactions. [14][15][16] Among these, C-H activation by metal-carbene-induced C-H insertion has received widespread attention and could achieve high siteand enantioselectivity without the need for a directing group or an external oxidant.…”

Ultrasound-promoted synthesis of a copper–iron-based catalyst for the microwave-assisted acyloxylation of 1,4-dioxane and cyclohexene

“…The activation of C-H bonds is an effervescent area of work in organic synthesis. [1][2][3][4][5][6][7] The stringent demands that the current concerns on sustainability pose on the chemical industry require the seeking of new methods for the preparation of high-value commodities. [8][9][10] In this scenario, the development of new catalysts that enables the introduction of oxygenated functions into C(sp 3 )-H bonds is a challenge undertaken by many research groups.…”