C-cells in colloid goiter

Lima, Marcus Aurelho de; Tiveron, Fabiana Sucupira; Santos, Vitorino Modesto dos; Lima, Lilian M. B.; Silva, Gilberto P.; Borges, Maria F.

doi:10.1590/s0041-87812003000600004

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…4 It has also been suggested that thyroid function control factors, such as C cells, can alter iodine levels, leading to goitre. 7 According to some studies, iodine deficiency is associated with a 5-10% prevalence of goitre. 8,9 The peak age for the onset of goitre is 35-50 years, and the ratio of women to men affected by goitre is 3:1.…”

Section: Aetiology and Epidemiologymentioning

confidence: 99%

A Review of the Pathology, Diagnosis and Management of Colloid Goitre

Hoang

Trinh

2020

European Endocrinology

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Section: Aetiology and Epidemiologymentioning

confidence: 99%

A Review of the Pathology, Diagnosis and Management of Colloid Goitre

Hoang

Trinh

2020

European Endocrinology

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“…Distribuição (Fig. 78): Brasil [Goiás, Distrito Federal, Mato Grosso do Sul, Minas Gerais (Monné & Giesbert, 1994), Espírito Santo, Rio de Janeiro (Costa Lima, 1955), São Paulo (Costa Lima, 1936), Paraná (Silva et al, 1968), Santa Catarina , Rio Grande do Sul (Buck, 1959)].…”

Section: Fêmea: Desconhecidaunclassified

Revisão do gênero Polyrhaphis Audinet-Serville (Coleoptera, Cerambycidae, Lamiinae)

2010

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Polyrhaphis Audinet-Serville, 1835, gênero de Lamiinae distribuído entre o México e América do Sul (excluindo o Chile e abaixo da latitude 35°S), é revisado. Três espécies novas são descritas: P. baloupae, procedente da Guiana Francesa; P. lanei, proveniente do Brasil (Amazonas e Pará); e P. peruana, do Peru. Duas espécies são sinonimizadas: P. testacea Lane, 1965 (= P. gracilis Bates, 1862) e P. paraensis [= P. papulosa (Olivier, 1795)]. É designado neótipo para P. papulosa. A autoria de P. horrida [= P. spinosa (Drury, 1773)] é discutida. Cerambyx armatus Voet (1778?) é considerado um nome inválido e Lamia armiger Schöenherr, 1817 (= Polyrhaphis armiger) o nome válido dessa espécie. Polyrhaphis spinipennis Laporte, 1840, é excluída da fauna da Colômbia. Novos registros de distribuição: P. argentina Lane, 1978, para o estado de São Paulo (Brasil); P. batesi Hovore & McCarty, 1998, para o Equador; P. belti Hovore & McCarty, 1998 para o Equador e Colômbia; P. gracilis Bates, 1862, para a guiana Francesa; e P. turnbowi Hovore & McCarty, 1998, em dúvida, para o Peru. É apresentada chave para as espécies do gênero.

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Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation

et al. 2010

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Liraglutide is a glucagon-like peptide-1 (GLP-1) analog developed for type 2 diabetes. Long-term liraglutide exposure in rodents was associated with thyroid C-cell hyperplasia and tumors. Here, we report data supporting a GLP-1 receptor-mediated mechanism for these changes in rodents. The GLP-1 receptor was localized to rodent C-cells. GLP-1 receptor agonists stimulated calcitonin release, up-regulation of calcitonin gene expression, and subsequently C-cell hyperplasia in rats and, to a lesser extent, in mice. In contrast, humans and/or cynomolgus monkeys had low GLP-1 receptor expression in thyroid C-cells, and GLP-1 receptor agonists did not activate adenylate cyclase or generate calcitonin release in primates. Moreover, 20 months of liraglutide treatment (at >60 times human exposure levels) did not lead to C-cell hyperplasia in monkeys. Mean calcitonin levels in patients exposed to liraglutide for 2 yr remained at the lower end of the normal range, and there was no difference in the proportion of patients with calcitonin levels increasing above the clinically relevant cutoff level of 20 pg/ml. Our findings delineate important species-specific differences in GLP-1 receptor expression and action in the thyroid. Nevertheless, the long-term consequences of sustained GLP-1 receptor activation in the human thyroid remain unknown and merit further investigation.

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C-cells in colloid goiter

Abstract: These results demonstrate a significant decrease of C-cell number in the colloid goiter group compared with control group, indicating that the hyperplastic process is restricted to follicular cells, to the detriment of C-cells, which probably cease to receive trophic stimuli.

Cited by 3 publications

References 17 publications

A Review of the Pathology, Diagnosis and Management of Colloid Goitre

A Review of the Pathology, Diagnosis and Management of Colloid Goitre

Revisão do gênero Polyrhaphis Audinet-Serville (Coleoptera, Cerambycidae, Lamiinae)

Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation

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