c-AMP und c-GMP als Indikatoren der Stimulation peripherer Rezeptoren bei Operationsstreß

Brisse, B; Tetsch, P; Toye, Ashley M; Bender, F.

doi:10.1007/978-3-642-85454-5_320

Cited by 1 publication

(2 citation statements)

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“…Alternatively, recent studies (Clutter et al, 1980) suggest that the mild receptor stimulation produced by a 3-adrenoceptor blocker such as pindolol with a pronounced ISA may lead to an increase in catecholamine clearance and this could be the underlying mechanism involved in the reduction in catecholamine levels after the drug. Whatever the mechanism, the results presented here are in agreement with those of other authors (Brecht et al, 1976 as a reflection of peripheral 02-adrenoceptor stimulation (Brisse et al, 1979;Wagner et al, 1979).…”

Section: Resultssupporting

confidence: 93%

“…Whatever the mechanism, the results presented here are in agreement with those of other authors (Brecht et al, 1976) who reported a reduction in plasma catecholamine levels during long term antihypertensive therapy with pindolol. c-AMP is known to be a mediator of the cellular responses to ,B-adrenoceptor stimulation and changes in the plasma concentrations of c-AMP may be taken as a reflection of peripheral 02-adrenoceptor stimulation (Brisse et al, 1979;Wagner et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Beta‐adrenoceptor blockade in stress due to oral surgery.

Brisse¹,

Tetsch²,

Jacobs³

et al. 1982

Brit J Clinical Pharma

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1 The effects of a single oral dose of 5 mg pindolol (P) and 100mg metoprolol (M) were assessed in a double-blind study in 30 patients undergoing oral surgery. 2 Systolic and diastolic blood pressures and heart rate were reduced 90 min after oral medication and did not exceed initial values at rest during the procedure. 3 Noradrenaline, adrenaline and c-AMP concentrations did not differ at any time from the control values at rest after P, but were increased after local anaesthesia and during oral surgery after M as were the metabolic responses reflected by plasma concentrations of glucose and free-fatty acids. 4 Plasma levels of ACTH and cortisol showed the typical increase during the procedure, being independent of ,B-adrenoceptor blockade. In contrast to the cardioselective antagonist M, prophylactic administration of the non-selective drug P prevented the sympathetic and metabolic responses to the stress of oral surgery.5 Hypothalamic and adrenal stimulation were not reduced by either selective or non-selective ,B-adrenoceptor blockade.

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Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%