c-abl Upregulates The Transcriptional Activity of ERβ by Their Interaction

Gao, Yuan; Chen, Xuan-Nan; Wei, Congwen; Zheng, Zhu-Jun; Hanson, Mark A.; Ni, Caifei; Song, Ting; Qi, Guoxian; Zhong, Hui; He, Xiaoqing

doi:10.3724/sp.j.1206.2009.00466

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Important Genes In Npc Carcinogenesis1

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2011

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“…Our methodology combined the study of a single gene with both genomic and proteomic approaches, and we obtained the same results with both methods, providing an important basis for functional genomic studies of NPC. In further studies, we found that NAG7 could inhibit estrogen receptor alpha (ER-α) [134] expression in NPC cells, activate the H-ras/p-c-raf, JNK/AP-1, and AKT/p70s6k signaling pathways, and regulate genes such as CAV1, MMP1 and EZR, thus promoting the metastatic ability of NPC cells [135].…”

Section: Important Genes In Npc Carcinogenesismentioning

confidence: 99%

Nasopharyngeal carcinoma: Advances in genomics and molecular genetics

Zeng

Huang

Zhang

et al. 2011

Sci. China Life Sci.

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Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution, being of high prevalence in southern China but rare in other parts of the world [2]. Familial clustering of NPC has been observed in diverse populations [3]. Elevated levels of circulating free Epstein-Barr virus (EBV) DNA and EBV-related antibodies in sera, as well as EBV DNA in tumor cells, have been consistently detected in individuals with NPC [4,5]. These studies have revealed that the risk factors of NPC are both environmental and genetic. How the risk factors interact, and the genes that are involved in the development of NPC, are not well understood [6].

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Section: Important Genes In Npc Carcinogenesismentioning

confidence: 99%