C(3)1-TAg in C57BL/6 J background as a model to study mammary tumor development

Sena, Isadora F. G.; Rocha, Beatriz G S; Picoli, Caroline C.; Santos, Gabryella S P; Costa, Alinne C.; Gonçalves, Bryan Ôrtero Perez; Garcia, Ana Paula V; Soltani-Asl, Maryam; Coimbra-Campos, Leda M C; Silva, Walison N.; Costa, P.A.C.R.; Pinto, Mauro Cunha Xavier; Amorim, Jaime Henrique; Azevedo, Vasco; Resende, Rodrigo R.; Heller, Débora; Cassali, Geovanni Dantas; Mintz, Akiva; Birbrair, Alexander

doi:10.1007/s00418-021-01995-w

Cited by 9 publications

(2 citation statements)

References 142 publications

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“…Cells were washed twice and the data was acquired. Ki67 is a nuclear factor transcript in the late G1, S, G2, and M of cell cycle, therefore marks proliferating cells [ 44 , 128 ]. Thus, we evaluated proliferation in viable CD45 negative cells, suggesting tumoral proliferation.…”

Section: Methodsmentioning

confidence: 99%

Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

Costa

Silva

Prazeres

et al. 2021

acta neuropathol commun

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Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Receptors Exclusively Activated by a Designer Drug (DREADD) technology to inhibit or activate sensory neurons’ firing within the melanoma tumor. Melanoma growth and angiogenesis were accelerated following inhibition of sensory neurons’ activity and were reduced following overstimulation of these neurons. Sensory neuron-specific overactivation also induced a boost in the immune surveillance by increasing tumor-infiltrating anti-tumor lymphocytes, while reducing immune-suppressor cells. In humans, a retrospective in silico analysis of melanoma biopsies revealed that increased expression of sensory neurons-related genes within melanoma was associated with improved survival. These findings suggest that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes.

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Section: Methodsmentioning

confidence: 99%

Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

Costa

Silva

Prazeres

et al. 2021

acta neuropathol commun

Self Cite

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show abstract

“…It will be interesting to examine whether SARS-Cov-2 virus activates the sympathetic nerve-brown adipocyte axis to produce IL-6. During the pandemic, patients also suffer with social isolation what leads to acute psychological stress, with the possible involvement of sympathetic nerves in the production of IL-6 remain incompletely understood within the complexity of the tumor microenvironment [133,136].…”

Section: Interactions Within the Tumor Microenvironmentmentioning

confidence: 99%