C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography

Schön, H. R.; Schelbert, Heinrich R.; Najafi, Ahmad; Hansen, Herbert; Huang, Henry; Barrio, Jorge R.; Phelps, Michael E.

doi:10.1016/0002-8703(82)90342-8

Cited by 139 publications

(7 citation statements)

References 23 publications

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“…Nine adult mongrel dogs weighing [24][25][26][27][28][29][30][31][32][33][34][35] kg (mean, 28.2+3.2 kg) were studied. Animals were anesthetized with sodium thiamylal (Surital) 2 mg/kg i.v.…”

Section: Animal Instrumentationmentioning

confidence: 99%

Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium.

et al. 1992

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Background. Prolonged metabolic abnormalities have been demonstrated previously in postischemic myocardium, including relative increases in glucose uptake and abnormal fatty acid kinetics. However, quantitative metabolic information is limited, and the time course of changes in MVo2 in postischemic myocardium is unknown. To address these issues, chronically instrumented dogs were studied serially over 1 month after transient left anterior descending coronary artery (LAD) occlusion, using positron emission tomography.Methods and Results. Dynamic imaging protocols were used in conjunction with tracer kinetic models to quantify blood flow and metabolic rates. Myocardial sectors were defined as normal, predominantly reversibly injured, and infarct-containing, based on occlusion blood flow images and postmortem histochemistry. Myocardial blood flow and metabolism were homogeneous at baseline. During LAD occlusion for 3 hours, myocardial blood flow in reversibly injured and infarct-containing sectors (determined with 13NH3) was decreased to 46% and 23%, respectively, of blood flow in normal tissue.

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Section: Animal Instrumentationmentioning

confidence: 99%

Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium.

et al. 1992

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“…Several investigators have reported that the clearance curve of 11 Cpalmitate is bi-exponential: the early rapid phase reflects -oxidation of fatty acid and the late slow phase represents turnover of the esterified lipid pool. [6][7][8]10,[23][24][25] Schöhn et al reported that in canine hearts, the relative extent of the early rapid clearance of 11 C-palmitate to the total clearance and the half-time of the early rapid clearance curve correlate closely with regional myocardial oxygen consumption and also to the rate of 11 CO2 production in normal and ischemic myocardium. 23,24 In human studies, because clearance of 11 C-palmitate is slower than in animal hearts, monoexponential curve fitting has often been used for quantitative assessment of the early rapid phase of 11 Cpalmitate clearance.…”

Section: Monoexponential Fitting In the Evaluation Of Fatty Acid -Oximentioning

confidence: 99%

“…The myocardial regions having good fatty acid -oxidation should have a relatively higher initial 11 C-palmitate uptake and greater percent clearance. 23,24 Initial Myocardial 11 …”

Section: Monoexponential Fitting In the Evaluation Of Fatty Acid -Oximentioning

confidence: 99%

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Evaluation of Fatty Acid .BETA.-Oxidation in Patients With Prior Myocardial Infarction in Relation to Myocardial Blood Flow, Total Oxidative Metabolism, and Left Ventricular Wall Motion

Miyabe

Ohte

Iida³

et al. 2005

Circ J

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“…Myocardial ischaemia prolonged the halftime of the rapid clearance phase, reflecting impaired tissue oxidative metabolic reserve (Lerch et al 1982;Rosamond et al 1989;Sch6n et al 1982).…”

Section: Ischaemic Heart Disease and Myocardial Viabilitymentioning

confidence: 99%

Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission

Syrota¹,

Jehenson²

1991

Eur J Nucl Med

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The three techniques allowing the noninvasive study of cardiac metabolism, namely magnetic resonance spectroscopy (MRS), positron emission tomography (PET) and single photon emission computed tomography (SPET), all use external detection with stable or radioactive isotopes. These techniques yield different information. PET is quantitative and very sensitive, and therefore only tracer amounts of molecules need to be injected. It allows neurotransmitters and receptors to be studied and a global view of metabolism (oxygen consumption, glucose and fatty acid utilization) to be obtained. SPET also has good sensitivity, but uses gamma-emitting isotopes of heteroatoms. Their longer half-lives allow follow-up for hours or days. MRS is based on stable elements with high (hydrogen 1, phosphorus 31, fluorine 19...) or low (carbon 13, Deuterium) natural abundance. It has very low sensitivity and only millimolar concentrations of substrates can be detected, but various parts of metabolism can be studied. The in vivo measurement of myocardial concentration of substances has many problems that are common to all three techniques (measurement of the volume, measurement of the quantity of each molecule, resolution, partial volume effect, improvement of the signal-to-noise ratio, movement of the organ). The complementarity of the techniques is illustrated by their applications to the study of cardiac metabolism. For instance, the energy metabolism can be studied by 31P-MRS, which detects the high-energy compounds ATP and phosphocreatine, and 13C-MRS yields information on the tricarboxylic acid cycle activity. PET and SPET allow the utilization of fatty acids, the normal fuels of the heart, to be studied. During ischaemia, PET with 18F-fluorodeoxyglucose (18FDG) can determine the glucose consumption and 1H-MRS shows the increase in lactic acid, reflecting anaerobic glycolysis. Comparison of the use of acetate labelled with 11C for PET or 13C for MRS shows the potentials and limitations of each technique. Myocardial perfusion can be evaluated directly with various PET tracers or indirectly with thallium 201 or various technetium-99m-labelled tracers by SPET. No MRS marker of perfusion is so far clinically available. Mainly SPET and PET are used clinically for the investigation of ischaemic heart disease as well as cardiomyopathies, but some initial results using 31P-MRS are being obtained.

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C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography

Cited by 139 publications

References 23 publications

Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium.

Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium.

Evaluation of Fatty Acid .BETA.-Oxidation in Patients With Prior Myocardial Infarction in Relation to Myocardial Blood Flow, Total Oxidative Metabolism, and Left Ventricular Wall Motion

Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission

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