Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.01.071 View full text
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Jani Siitonen, Tuomo Sainio, Arvind Rajendran

Abstract: The possibility to improve the performance of batch chromatographic separations by using so-called bypass method is analyzed for the first time. In bypass chromatography, only a part of the feed is introduced into the column and purified to purity larger than the desired value. The resulting fractions are then blended with fresh feed to match the given purity constraints. A general approach is presented for designing bypass batch chromatography. Analytical design equations, based on equilibrium theory of chrom…

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