By regulating the IP3R/GRP75/VDAC1 complex to restore mitochondrial dynamic balance, selenomethionine reduces lipopolysaccharide‐induced neuronal apoptosis
Anqi Xu,
Yixuan Wang,
Dongliu Luo
et al.
Abstract:Selenium (Se), as one of the essential trace elements, plays an anti‐inflammatory, antioxidation, and immune‐enhancing effect in the body. In addition, Se can also improve nervous system damage induced by various factors. Earlier studies have described the important role of mitochondrial dynamic imbalance in lipopolysaccharide (LPS)‐induced nerve injury. The inositol 1,4,5‐triphosphate receptor (IP3R)/glucose‐regulated protein 75 (GRP75)/voltage‐dependent anion channel 1 (VDAC1) complex is considered to be the… Show more
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