By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth

Li, Zheng; Yu, Xin; Wang, Yang; Shen, Jianxiong; Wu, William Ka Kei; Liang, Jinqian; Feng, Fan

doi:10.18632/oncotarget.2755

Cited by 94 publications

(77 citation statements)

References 44 publications

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“…Increasing evidence has confirmed that loss of tumor suppressor genes is one of the crucial steps in the progression of cancers [19][20][21]. In our study, PAQR3 acted as a tumor suppressive gene in the tumorigenesis of LSCC.…”

Section: Discussionsupporting

confidence: 73%

PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma

Zhuang

2015

Tumor Biol.

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Laryngeal squamous cell carcinoma (LSCC) is a common type of head and neck malignancy worldwide. The molecular mechanism of LSCC remains not well understood. PAQR3 (progestin and AdipoQ receptors) is a member of the progestin and adipoQ receptor (PAQR) family. Many studies have showed that PAQR3 acts as a new tumor suppressor. However, its expression and functions in LSCC are still unknown. In our study, the expression of PAQR3 was downregulated in human LSCC tissues compared to that in adjacent tissues. Moreover, overexpression of PAQR3 suppressed LSCC cell proliferation and invasion. In addition, PAQR3 inhibited cell proliferation and invasion by regulating ERK phosphorylation. In conclusion, our data demonstrated that PAQR3 acted a tumor suppressive role in LSCC, providing a novel diagnostic and therapeutic option for LSCC in the future.

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Section: Discussionsupporting

confidence: 73%

PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma

Zhuang

2015

Tumor Biol.

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“…Recent studies showed that miRNAs play vital roles in regulating individual development, cell proliferation, metabolism, differentiation, invasion and migration in different disease [16-22]. A number of studies dispalyed that different miRNAs could increase or decrease cell apoptosis in OA, such as miR-149 and miR-30b [23, 24].…”

Section: Introductionmentioning

confidence: 99%

MiR-1246 Promotes LPS-Induced Inflammatory Injury in Chondrogenic Cells ATDC5 by Targeting HNF4γ

Zhang

Wang

et al. 2017

Cell Physiol Biochem

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Background/Aims: Osteoarthritis (OA) is a common inflammatory joint disease. miRNAs are associated with OA and functionally implicated in the pathogenesis of the disease. In the present study, we investigated the role of miR-1246 in the lipopolysaccharide (LPS)-induced inflammatory injury of ATDC5 cells. Methods: ATDC5 cells were cultured and treated with LPS in a series of concentration (0, 1, 5, and 10 µg/ml) for 5 h. The cells were transfected with miR-1246-mimic, inhibitor, si-HNF4γ or negative control, then were assessed for cell viability using CCK8 assay, apoptosis by flow-cytometry and expressions of miR-1246 and pro-inflammatory cytokines by qRT-PCR and western blot analysis. Results: Cell viability was significantly reduced and cell apoptosis was added in ATDC5 cells injured with LPS at the dosage of 5 and 10 µg/ml. Relative mRNA expressions of pro-inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α) were significantly increased. miR-1246 was up-regulated in ATDC5 cells treated with LPS. Moreover, miR-1246 overexpression aggravated LPS-induced decrease in cell viability, increase in apoptosis and overproduction of pro-inflammatory factors. mRNA and protein expressions of HNF4γ were significantly suppressed in cells transfected with miR-124-mimic. Further, miR-1246 knockdown alleviated LPS-induced inflammatory injury by up-regulating the expression of HNF4γ and activation of PI3K/AKT and JAK/STAT pathways. Conclusions: Suppression of miR-1246 alleviated LPS-induced inflammatory injury in chondrogenic ADTC5 cells by up-regulation of HNF4γ and activation of PI3K/AKT and JAK/STAT pathways. The findings of this study will provide a novel viewpoint regarding miR-1246 target for clinical.

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“…www.impactjournals.com/oncotarget Furthermore, our study displayed that miR-329 restricted cell growth by enhancing the level of several apoptosis prone proteins. Recently, it has been reported that miR-329 played tumor suppressive role by targeting different molecules in several cancers [18][19][20]. Due to miR-329 mainly inhibited cell growth in pancreatic cancer, in this study, we uncovered the miR-329-target network which was closely associated with cell proliferation and apoptosis by bioinformatic analysis.…”

Section: Discussionmentioning

confidence: 95%

“…MiR-329 was reported to promote tumor growth or metastasis in glioma, neuroblastoma and gastric cancer at decreased expression level [18][19][20]. However, the expression and function of miR-329 in pancreatic cancer is still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…By a comprehensive study of the published literatures [17][18][19][20][21], we have uncovered that miR-329, which is located on 14q32.31 [17], is potential to regulate cancer progression. It was found that miR-329 downregulated E2F1 expression and inhibited glioma cells proliferation [18], also, miR-329 suppressed tumor invasion and growth by targeting TIAM1 in gastric cancer [19]. Recently, miR-329 was found to inhibit cell growth and motility in neuroblastoma by targeting LSD1 [20,21].…”

Section: Introductionmentioning

confidence: 99%

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