BWV 131a Fugue in G minor

Williams, Peter

doi:10.1017/cbo9780511481871.002

Cited by 7 publications

(8 citation statements)

References 97 publications

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“…Typically, encounters at a distance greater than ∼ 3 Hill radii will have only a limited effect on the long term stability of an object, whilst orbits that approach within this distance are typically dynamically unstable, unless close approaches are prevented by mutual meanmotion resonances between the objects concerned (e.g. Williams & Benson 1971;Malhotra 1995;Horner et al 2011;Robertson et al 2012;Wittenmyer et al 2012).…”

Section: Measuring the Severity Of Close Encounters With Planetsmentioning

confidence: 99%

The Dynamical History of 2060 Chiron and Its Proposed Ring System

Wood

Horner

Hinse

et al. 2017

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The surprising discovery of a ring system around the Centaur 10199 Chariklo in 2013 led to a reanalysis of archival stellar occultation data for the Centaur 2060 Chiron by Ortiz et al. (2015). One possible interpretation of that data is that a system of rings exists around Chiron.In this work, we study the dynamical history of the proposed Chiron ring system by integrating almost 36,000 clones of the Centaur backwards in time for 100 Myr under the influence of the Sun and the four giant planets. The severity of all close encounters between the clones and planets while the clones are in the Centaur region are recorded along with the mean time between close encounters.We find that severe and extreme close encounters are very rare, making it possible that the Chiron ring system has remained intact since its injection into the Centaur region, which we find likely occurred within the past 8.5 Myr. Our simulations yield a backwards dynamical half-life for Chiron of 0.7 Myr. The dynamical classes of a sample of clones are found. It is found that, on average, the Centaur lifetimes of resonance hopping clones are twice those of random-walk clones because of resonance sticking in mean motion resonances.In addition, we present MEGNO and chaotic lifetime maps of the region bound by 13 au ≤ a ≤ 14 au and e ≤ 0.5. We confirm that the current mean orbital parameters of Chiron are located in a highly chaotic region of a − e phase space.

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Section: Measuring the Severity Of Close Encounters With Planetsmentioning

confidence: 99%

The Dynamical History of 2060 Chiron and Its Proposed Ring System

Wood

Horner

Hinse

et al. 2017

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“…The NBDs directly bind to dsDNA 7,90,91 and also interact with the nuclease dimer Mre11. [92][93][94] In the presence of hydrolysable ATP, Rad50's NBDs activate Mre11's exonuclease and endonuclease activities to cleave 5 0 strands near DNA double-strand breaks 95 . The precise mechanism is still rather unclear and may include unwinding of DNA 90 or structural modulation of the Mre11 dimer.…”

Section: Chromosome Segregation and Dna Repair Abc Proteinsmentioning

confidence: 99%

“…A "signature coupling" helix, which is situated between the Q-loop and the adjoining coiled-coil domains plays together with the coiled-coil domain important functional roles in the allosteric coupling of the ATPase with the DNA binding and nuclease activities. 94,107,127 Recent results showed that also DNA binds via its backbone strands along the NBD dimer groove on lobes I and II (Figure 5b). Intriguingly the coupling helices of ABC transporters and the DNA strands at Rad50 occupy similar positions and reveal an unexpected convergent functional architecture with respect to allosteric control and chemo-mechanical coupling (Figure 5c).…”

Section: Chemo-mechanical Coupling and Allosteric Controlmentioning

confidence: 99%

Invited review: Architectures and mechanisms of ATP binding cassette proteins

Hopfner

2016

Biopolymers

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ATP binding cassette (ABC) ATPases form chemo-mechanical engines and switches that function in a broad range of biological processes. Most prominently, a very large family of integral membrane NTPases -ABC transporters -catalyzes the import or of a diverse molecules across membranes. ABC proteins are also critical components of the chromosome segregation, recombination and DNA repair machineries and regulate or catalyze critical steps of ribosomal protein synthesis. Recent structural and mechanistic studies draw interesting architectural and mechanistic parallels between diverse ABC proteins. Here I review the current state of our understanding how NTP-dependent conformational changes of ABC proteins drive diverse biological processes.

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“…With the use of calcium sensitive dyes (e.g., fura-2 and fluo-3), the concentration changes of calcium ions in different kinds of neurons and glial cells [14][15][16][17][18] have been successfully exploited, and great progress has been achieved with respect to various pathways in which calcium ions are involved to provide understanding of the nature of activities in the brain.…”

Section: Fluorescence Microscopic Methodsmentioning

confidence: 99%

Selective detection of neurotransmitters by fluorescence and chemiluminescence imaging

Wang

Yeung

2001

Pure and Applied Chemistry

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In recent years, luminescence imaging has been widely employed in neurochemical analysis. It has a number of advantages for the study of neuronal and other biological cells: (1) a particular molecular species or cellular constituent can be selectively visualized in the presence of a large excess of other species in a heterogeneous environment; (2) low concentration detection limits can be achieved because of the inherent sensitivity associated with fluorescence and chemiluminescence; (3) low excitation intensities can be used so that long-term observation can be realized while the viability of the specimen is preserved; and (4) excellent spatial resolution can be obtained with the light microscope so subcellular compartments can be identified. With good sensitivity, temporal and spatial resolution, the flux of ions and molecules and the distribution and dynamics of intracellular species can be measured in real time with specific luminescence probes, substrates, or with native fluorescence. A noninvasive detection scheme based on glutamate dehydrogenase (GDH) enzymatic assay combined with microscopy was developed to measure the glutamate release in cultured cells from the central nervous system (CNS). The enzyme reaction is very specific and sensitive. The detection limit with CCD imaging is down to µM levels of glutamate with reasonable response time. We also found that chemiluminescence associated with the ATP-dependent reaction between luciferase and luciferin can be used to image ATP at levels down to 10 nM in the millisecond time scale. Similar imaging experiments should be feasible in a broad spectrum of biological systems.

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BWV 131a Fugue in G minor

Cited by 7 publications

References 97 publications

The Dynamical History of 2060 Chiron and Its Proposed Ring System

The Dynamical History of 2060 Chiron and Its Proposed Ring System

Invited review: Architectures and mechanisms of ATP binding cassette proteins

Selective detection of neurotransmitters by fluorescence and chemiluminescence imaging

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