Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells

Onder, Seda; Schopfer, Lawrence M.; Jiang, Wei; Tacal, Özden; Lockridge, Oksana

doi:10.1016/j.neuro.2022.02.006

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…56,57 Its promiscuity, extensive distribution throughout the body, lack of a known physiological function, and promiscuity make it a desirable pharmaceutical target. 58,59 The discovery that BChE activity positively linked with plasma triglyceride levels ignited a fervent interest in the study of the connection between BChE and the lipid metabolism. According to the investigations that followed, BChE activity was also linked with other lipid metabolism indicators or even insulin resistance.…”

Section: Resultsmentioning

confidence: 99%

“…An innovative therapeutic target is butyrylcholinesterase (BChE), known as a serine hydrolase, interacts with numerous endogenous and exogenous esters 56,57 . Its promiscuity, extensive distribution throughout the body, lack of a known physiological function, and promiscuity make it a desirable pharmaceutical target 58,59 . The discovery that BChE activity positively linked with plasma triglyceride levels ignited a fervent interest in the study of the connection between BChE and the lipid metabolism.…”

Section: Resultsmentioning

confidence: 99%

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Assessment of hypolipidemic and anti‐inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR‐1339‐induced hyperlipidemia in rat kidney, liver, and heart

Palabıyık

Sulumer

Uguz

et al. 2022

J of Molecular Recognition

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Atherosclerosis and cognitive impairment are both influenced by hyperlipidemia. Due to their high margin of safety and low cost, natural chemicals have recently attracted particular attention in the context of the treatment of disease. Hence, the purpose of this study was to investigate the possible amendatory impact of ethanol extract walnut (Juglans regia) seed coat (E‐WSC) on some metabolic enzymes (glutathione reductase (GR), paraoxonase‐1 (PON1), aldose reductase (AR), sorbitol dehydrogenase (SDH), acetylcholinesterase (AChE), glutathione S‐transferase (GST), and butyrylcholinesterase (BChE)) activity in the liver, kidney, and heart of rats with Triton WR‐1339‐induced hyperlipidemia. Rats were divided into five groups: control group, HL‐Control group (Triton WR‐1339 400 mg/kg, i.p administered group), E‐ WSC + 150 (150 mg/kg,o.d given group), E‐ WSC + 300 (E‐ WSC 300 mg/kg, o.d given group) and HL+ E‐WSC + 300 (Group receiving E‐ WSC 300 mg/kg, o.d 30 min prior to administration of Triton WR‐1339 400 mg/kg, i.p). In HL‐Control, AR, SDH, and BChE enzyme activity was significantly increased in all tissues compared to the control, while the activity of other studied enzymes was significantly decreased. The effects of hyperlipidemia on balance were improved and alterations in the activity of the investigated metabolic enzymes were prevented by E‐WSC. As a result, promising natural compounds that can be used as adjuvant therapy in the treatment of cognitive disorders and hyperlipidemia may be found in E‐WSC powder.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Assessment of hypolipidemic and anti‐inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR‐1339‐induced hyperlipidemia in rat kidney, liver, and heart

Palabıyık

Sulumer

Uguz

et al. 2022

J of Molecular Recognition

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“…2). [81][82][83][84][85][86][87][88][89][90][91][92][93] Accordingly, the monitoring of BChE becomes a highly important task due to potential involvement of BChE in physiological and pathological processes, as well as its association with various conditions.…”

Section: Jefferson Chanmentioning

confidence: 99%

Optical imaging probes for selective detection of butyrylcholinesterase

Dirak,

Chan,

Kolemen

2024

J. Mater. Chem. B

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“…For instance, elevated expression of tumor associated BChE has been shown to be related to the development of neuroblastoma, demonstrating its potential as a tumor biomarker. [29][30][31][32][33][34][35][36][37][38] Considering broad contributions of BChE to physiological and pathological processes, it is of great importance to monitor BChE activity and its spatial/temporal distributions in living cells with a high selectivity and sensitivity.…”

Section: Introductionmentioning

confidence: 99%