Butyrylcholinesterase in metabolic syndrome

Sridhar, G. R.; Rao, Allam Appa; Srinivas, Kudipudi; Nirmala, G; Lakshmi, Gumpeny; Suryanarayna, Dasika; Rao, Padmanabhuni Venkata Nageswara; Kaladhar, Dowluru Svgk; Kumar, Sali Veeresh; Devi, T. Uma; Nitesh, Turaga; Thota, Hanuman

doi:10.1016/j.mehy.2010.08.008

Cited by 33 publications

(25 citation statements)

References 41 publications

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“…A series of other studies have suggested that it could be one of the mediators between type 2 diabetes mellitus and Alzheimer's disease [39]. Of greater interest is the potential of evaluating individuals having variant butyrylcholinesterase proteins and their susceptibility or protection from metabolic syndrome and its associated abnormalities [40,41].…”

mentioning

confidence: 99%

Diabetes and data in many forms

Sridhar¹

2016

Int J Diabetes Dev Ctries

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mentioning

confidence: 99%

Diabetes and data in many forms

Sridhar¹

2016

Int J Diabetes Dev Ctries

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“…Among common pathogenic factors between DM and AD, BChE has been studied in vitro and in plasma (Sridhar et al 2006;Rao et al 2007;Shaikh et al 2014). Alterations in the level of plasma BChE occur in DM; variant forms of the plasma enzyme occur in both DM and AD (Sridhar et al 2010;Raygani et al 2004). In vitro studies demonstrate a common pathogenic mechanism (Sridhar et al 2006;Diamant et al 2006).…”

Section: Potential Role Of Butyrylcholinesterase In Linking Diabetes mentioning

confidence: 99%

The diabetic brain and cognition

et al. 2017

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The prevalence of both Alzheimer's disease (AD) and vascular dementia (VaD) is increasing with the aging of the population. Studies from the last several years have shown that people with diabetes have an increased risk for dementia and cognitive impairment. Therefore, the authors of this consensus review tried to elaborate on the role of diabetes, especially diabetes type 2 (T2DM) in both AD and VaD. Based on the clinical and experimental work of scientists from 18 countries participating in the International Congress on Vascular Disorders and on literature search using PUBMED, it can be concluded that T2DM is a risk factor for both, AD and VaD, based on a pathology of glucose utilization. This pathology is the consequence of a disturbance of insulin-related mechanisms leading to brain insulin resistance. Although the underlying pathological mechanisms for AD and VaD are different in many aspects, the contribution of T2DM and insulin resistant brain state (IRBS) to cerebrovascular disturbances in both disorders

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“…Although etiology of Alzheimer´s disease is not understood, there is evidence of link between BChE and disease development (58,59). The commonly accepted risk factor for Alzheimer´s disease is apolipoprotein E 4 (60).…”

Section: Dibucaine Numbermentioning

confidence: 99%

Butyrylcholinesterase as a biochemical marker

Pohanka¹

2013

BLL

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Butyrylcholinesterase (BChE) is an enzyme expressed in multiple organs and abundant in plasma. BChE can fl uctuate in course of several reasons while both hypercholiensterasemia and hypocholinesterasemia are known. Considering evidence of BChE activity alterations, hepatocellular carcinoma, chronic liver diseases and poisoning with carbamates or organophosphates can be diagnosed by activity assay. BChE is responsible for detoxifi cation reactions, and the compounds such as cocaine, succinylcholine, and acetylsalicylic acid are degraded in the body. The detoxifi cation can be slowed in patients carrying the K variant of the enzyme. Summarization of literature, discussion on the meaning of BChE in the body, and the principles of BChE assay in samples are described in the review (Tab. 2, Fig. 8, Ref. 86). Text in PDF www.elis.sk.

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Butyrylcholinesterase in metabolic syndrome

Cited by 33 publications

References 41 publications

Diabetes and data in many forms

Diabetes and data in many forms

The diabetic brain and cognition

Butyrylcholinesterase as a biochemical marker

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