Butyrogenic, bifidogenic and slight anti-inflammatory effects of a green kiwifruit powder (Kiwi FFG®) in a human gastrointestinal model simulating mild constipation

Goya-Jorge, Elizabeth; Bondue, Pauline; Gonza, Irma; Laforêt, Fanny; Antoine, Céline; Boutaleb, Samiha; Douny, Caroline; Scippo, Marie-Louise; de Ribaucourt, Jeoffrey Christyn; Crahay, Fabienne; Delcenserie, Véronique

doi:10.1016/j.foodres.2023.113348

Cited by 8 publications

(6 citation statements)

References 76 publications

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“…Despite the availability of many drugs for constipation treatment, their use is often associated with many side effects, such as good initial effect, poor long-term effect, drug dependence, thus there remains a pressing demand for more effective therapeutic options. 25…”

Section: Discussionmentioning

confidence: 99%

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Zhao,

Meng,

Sun

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Zhao,

Meng,

Sun

et al. 2024

Food Funct.

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“…Kiwifruits also contain a proteolytic enzyme, actinidin, which is shown in animal studies to accelerate gastric emptying, and is suggested to accelerate gut motility and affect pain reception and anti‐inflammatory responses in the gut through protease‐activated receptors, which could explain effects in improving gastrointestinal symptoms 52–54 . Kiwifruit may also have butyrogenic, bifidogenic, and anti‐inflammatory effects, observed in a human gastrointestinal model of constipation 55 . Prunes were studied in two trials; one was exploratory, partially randomised and not powered to detect effectiveness, and in another, it was unclear whether the study was powered as a non‐inferiority or equivalence trial 24,25 .…”

Section: Discussionmentioning

confidence: 99%

“…including all or most aspects of the diet including meals and food groups) in a form that could be widely applied in practice. Surprisingly, only one RCT administering a high‐fibre diet (25–30 g/day) was identified, and this was halted before reaching the expected sample size due to lack of efficacy, after having no impact on response to treatment or stool output, and worsening flatulence and abdominal distention compared with a low‐fibre diet (15–20 g/day) 55 . This review is limited to include studies in chronic constipation only; however, studies administering a high‐fibre diet in secondary constipation have been performed, for example, an RCT in patients on peritoneal dialysis, also showing no effect when compared with placebo 61 .…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis: Foods, drinks and diets and their effect on chronic constipation in adults

Van Der Schoot,

Katsirma,

Whelan

et al. 2023

Aliment Pharmacol Ther

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SummaryBackgroundDietary approaches are recommended for the management of chronic constipation. Until now, there has been no systematic review and meta‐analysis on foods, drinks and diets in constipation.AimsTo investigate the effect of foods, drinks and diets on response to treatment, stool output, gut transit time, symptoms, quality of life, adverse events and compliance in adults with chronic constipation via a systematic review and meta‐analysis.MethodsStudies were identified using electronic databases (12th July 2023). Intervention trials (randomised controlled trials [RCTs], non‐randomised, uncontrolled) were included. Risk of bias was assessed using Cochrane 2.0 (RCTs) or JBI Critical Appraisal (uncontrolled trials). Data from RCTs only were synthesised using risk ratios (RRs), mean differences (MDs), standardised mean differences (95% CI) using random‐effects.ResultsWe included 23 studies (17 RCTs, 6 uncontrolled; 1714 participants): kiwifruit (n = 7), high‐mineral water (n = 4), prunes (n = 2), rye bread (n = 2), mango, fig, cereal, oat bran, yoghurt, water supplementation, prune juice, high‐fibre diet, no‐fibre diet (n = 1). Fruits resulted in higher stool frequency than psyllium (MD: +0.36 bowel movements [BM]/week, [0.25–0.48], n = 232), kiwifruits in particular (MD: +0.36 BM/week, [0.24–0.48], n = 192); there was no difference for prunes compared with psyllium. Rye bread resulted in higher stool frequency than white bread (MD: +0.43 BM/week, [0.03–0.83], n = 48). High‐mineral water resulted in higher response to treatment than low‐mineral water (RR: 1.47, [1.20–1.81], n = 539).ConclusionsFruits and rye bread may improve certain constipation‐related outcomes. There is a scarcity of evidence on foods, drinks and diets in constipation and further RCTs are needed.

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“…Furthermore, regulation of human interleukin (IL-6 and IL-10) production in Caco-2 cells revealed a modest anti-inflammatory impact of kiwifruit powder and gut microbiota-derived metabolites. These findings suggested that Kiwi FFG® may help the gut microbiota, particularly in constipated persons [13] .…”

Section: Véronique Delcenserie Et Al (2023)mentioning

confidence: 90%

A comprehensive review of phytochemical and pharmacological properties of Actinidia deliciosa

Kumar,

Singh

et al. 2024

Int. J. Pharmacogn. Pharm. Res.

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Actinidia deliciosa is a fruiting vine. It is deciduous and woody. It consists of different species and cultivars with diverse traits and sensory properties. Various extracts of the plant have been utilized in traditional Chinese medicine to alleviate symptoms of many conditions. As Actinidia deliciosa becomes more popular, researchers focus on its health benefits such as increased antioxidant levels, improved gastrointestinal health, lower blood lipid levels, and relief from skin diseases. It can cause allergy symptoms in some individuals, prompting an investigation into its allergenicity across different groups. It also contains high levels of vitamin C, folate, potassium, and fiber. This fruit's minerals and phytochemicals have led to research on its antioxidant and anti-inflammatory properties, potentially preventing cardiovascular disease, cancer, and other chronic diseases.

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Butyrogenic, bifidogenic and slight anti-inflammatory effects of a green kiwifruit powder (Kiwi FFG®) in a human gastrointestinal model simulating mild constipation

Cited by 8 publications

References 76 publications

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Systematic review and meta‐analysis: Foods, drinks and diets and their effect on chronic constipation in adults

A comprehensive review of phytochemical and pharmacological properties of Actinidia deliciosa

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