Butyrate Increases Intracellular Calcium Levels and Enhances Growth Hormone Release from Rat Anterior Pituitary Cells via the G-Protein-Coupled Receptors GPR41 and 43

Miletta, Maria Consolata; Petkovic, Vibor; Eblé, Andrée; Ammann, Roland A.; Flück, Christa E.; Mullis, Primus-E.

doi:10.1371/journal.pone.0107388

Cited by 37 publications

(32 citation statements)

References 46 publications

(60 reference statements)

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“…Interestingly, recent studies showed that other mechanisms were found to interpret the function of SCFA like NaB on energy metabolism based on G-protein coupled receptors (GPCR). Miletta MC et al found that NaB increased intracellular calcium levels and enhanced growth hormone release from rat anterior pituitary cells via GPR41 and 43 42 . Moreover, the interaction of SCFA and GPR43 modulated colitis by regulating inflammatory cytokine production in mouse mononuclear cells 43 .…”

Section: Discussionmentioning

confidence: 99%

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway

Wang

Peng

et al. 2015

Sci Rep

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Insulin resistance (IR) is a common feature of Type II diabetes, metabolic disorders, hypertension and other vascular diseases. Recent studies showed that obesity-induced inflammation may be critical for IR. To investigate the anti-inflammatory effect of sodium butyrate (NaB) on obesity-induced inflammation, the db/db mice were intraperitoneally injected with NaB for 6 weeks. Glucose control was evaluated by glucose tolerance test (GTT) and insulin tolerance test (ITT). Adipose tissue was harvested for gene expression analysis. 3T3-L1 adipocytes were treated with Tnf-α to mimic the inflammatory state and gene expression was detected by realtime PCR and Western blotting. Our results showed that NaB treatment improved glucose control in db/db mice as determined by GTT and ITT tests. Gene expression analysis showed that NaB inhibited cytokines and immunological markers including CD68, Interferon-γ and Mcp in adipose tissues in db/db mice. Moreover, NaB inhibited cytokine releasing in 3T3-L1 adipocytes treated with TNF-α. Further analysis of inflammation pathway showed that NLRP3 was activated in db/db mice, which was efficiently inhibited by NaB treatment. Our data suggest that inhibition of obesity-induced inflammation alleviates IR, and NaB might be a potential anti-inflammatory agent for obesity.

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Section: Discussionmentioning

confidence: 99%

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway

Wang

Peng

et al. 2015

Sci Rep

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“…The regulation of the transporter is likely related to the direction of energy supplies to tissues during fasting. Moreover, Miletta and colleagues found that butyrate enhances growth hormone (GH) secretion in pituitary cells via GPR41/43 activation and intracellular accumulation of Ca 2+ (131). This leads to the hypothesis that butyrate acts as a secondary mediator of metabolic adaptations of GH during fasting, which mainly include increased lipolysis and protein retention.…”

Section: Scfas and Neuronsmentioning

confidence: 99%

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

2020

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A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions. In recent years, there has been growing recognition of the involvement of the gut microbiota in the modulation of multiple neurochemical pathways through the highly interconnected gut-brain axis. Although amazing scientific breakthroughs over the last few years have expanded our knowledge on the communication between microbes and their hosts, the underpinnings of microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids (SCFAs), the main metabolites produced in the colon by bacterial fermentation of dietary fibers and resistant starch, are speculated to play a key role in neuro-immunoendocrine regulation. However, the underlying mechanisms through which SCFAs might influence brain physiology and behavior have not been fully elucidated. In this review, we outline the current knowledge about the involvement of SCFAs in microbiota-gut-brain interactions. We also highlight how the development of future treatments for central nervous system (CNS) disorders can take advantage of the intimate and mutual interactions of the gut microbiota with the brain by exploring the role of SCFAs in the regulation of neuro-immunoendocrine function.

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“…Butyrate is a short‐chain fatty acid that is closely related to the ketone body β‐hydroxybutyrate in structure and function (George & Cahill, ; Shimazu et al, ). Butyrate is the principal energy source for intestinal epithelial cells, and is directly supplied by β‐oxidation (Miletta et al, ). In addition, TB supplementation improves the level of lipase and trypsin in piglets (Li et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of chromium yeast, tributyrin and bile acid on growth performance, digestion and metabolism ofChanna argus

Hou

Yao

et al. 2018

Aquac Res

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A 60-day feeding trial was carried out to evaluate the effects of chromium yeast (CY), tributyrin (TB) and bile acid (BA) on the snakehead (Channa argus). The control (CT) group was fed the basal diet, and the experimental groups were fed 200 mg/kg CY (concentration: 1,000 mg/kg), 2.5 g/kg TB (purity: 45%) or 1 g/kg BA (purity: 30%) in addition to the basal diet. The addition of CY, TB and BA statistically increased the weight gain rate, and specific growth rate, whereas the feeding rate and feed conversion ratio were significantly reduced (p < 0.05). When compared with the CT group, TB elevated the serum glutathion peroxidase (GSH-Px) activity; and BA reduced low density lipoprotein cholesterol (LDL-C) contents significantly (p < 0.05). The three feed additives reduced intestinal malonaldehyde (MDA) levels dramatically. Tributyrin significantly enhanced intestinal trypsin and pepsin activities (p < 0.05). The activity of fructose-1,6-bisphosphatase and pyruvate carboxylase in the group fed CY was significantly lower than in the CT group. In conclusion, dietary inclusion of the three additives enhanced growth performance of C. argus. Dietary supplementation of CY affected protein, glucose and lipid metabolism. Diets with TB levels improved intestinal digestive enzyme activity and antioxidant capacity. The addition of BA improved glycolipid metabolism. K E Y W O R D Sbile acid, chromium yeast, growth performance, snakehead, tributyrin

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Butyrate Increases Intracellular Calcium Levels and Enhances Growth Hormone Release from Rat Anterior Pituitary Cells via the G-Protein-Coupled Receptors GPR41 and 43

Cited by 37 publications

References 46 publications

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

Effects of chromium yeast, tributyrin and bile acid on growth performance, digestion and metabolism ofChanna argus

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